CD57/B3gat1 Protein, Human, Recombinant (mFc)

B3GAT1 is the key enzyme during the biosynthesis of the carbohydrate epitope HNK-1, which is present on a number of cell adhesion molecules important in neurodevelopment. Saturating concentrations of rVAR2 inhibited downstream integrin signaling, which was mimicked by knockdown of the core chondroitin sulfate synthesis enzymes β-1,3-glucuronyltransferase 1 (B3GAT1) and chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1).

Pack Size	Availability	Price/USD	Quantity
200 μg	5 days	$ 1,000.00

Pack Size

Availability

Price/USD

Quantity

200 μg

5 days

$ 1,000.00

Description

Species	Human
Expression System	HEK293 Cells
Tag	N-mFc
Accession Number	Q9P2W7-1
Synonyms	LEU7, NK1, beta-1,3-glucuronyltransferase 1, HNK1, GLCATP, NK-1, β-1,3-glucuronyltransferase 1, GLCUATP, CD57
Construction	The Human B3GAT1 (NP_473366.1) (Thr28-Ile334) was expressed with the Fc region of Mouse IgG1 at the N-terminus.
Protein Purity	> 90 % as determined by SDS-PAGE.
Molecular Weight	61.7 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	B3GAT1 is the key enzyme during the biosynthesis of the carbohydrate epitope HNK-1, which is present on a number of cell adhesion molecules important in neurodevelopment. Saturating concentrations of rVAR2 inhibited downstream integrin signaling, which was mimicked by knockdown of the core chondroitin sulfate synthesis enzymes β-1,3-glucuronyltransferase 1 (B3GAT1) and chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1).

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CD57/B3gat1 Protein, Human, Recombinant (mFc)

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