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Anti-IL-1R1 Antibody-PE (5P116)
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Catalog No. TMAY-03709P
Alias interleukin 1 receptor, type I
Anti-IL-1R1 Antibody-PE (5P116) is a PE-conjugated Rabbit antibody targeting IL-1R1. Anti-IL-1R1 Antibody-PE (5P116) can be used in FCM.
Anti-IL-1R1 Antibody-PE (5P116)
Anti-IL-1R1 Antibody-PE (5P116)
😃Good
Catalog No. TMAY-03709PAlias interleukin 1 receptor, type I
Anti-IL-1R1 Antibody-PE (5P116) is a PE-conjugated Rabbit antibody targeting IL-1R1. Anti-IL-1R1 Antibody-PE (5P116) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 T | $128 | 7-10 days | |
| 100 T | $256 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: FCM Reactivity: Rat |
| Alias | interleukin 1 receptor, type I |
| Ig Type | Rabbit IgG |
| Clone | 5P116 |
| Reactivity | Rat |
| Verified Activity | Flow cytometric analysis of Rat IL1R1(CD121a) expression on rat splenocytes. SD splenocytes were stained with PE-conjugated anti-Rat IL1R1(CD121a). The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Rat IL-1R1 / CD121a (rR IL-1R1 / CD121a; TMPY-02059; NP_037255.3; Met1-Lys352) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess. |
| Conjucates | PE |
| Others Formats | Unconjugated/FITC |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Protein: Rat IL-1R1 / CD121a protein (TMPY-02059) |
| Antigen Species | Rat |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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