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Ezatiostat hydrochloride

Name: Ezatiostat hydrochloride
Brand: TargetMol
SKU: T22776
Rating: 4.5 (1 reviews)

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Catalog No. T22776Cas No. 286942-97-0

Alias TLK199 HCl, TER199

Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.

Ezatiostat hydrochloride

😃Good

Catalog No. T22776Alias TLK199 HCl, TER199Cas No. 286942-97-0

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$53	6-8 weeks	6-8 weeks
5 mg	$75	6-8 weeks	6-8 weeks
10 mg	$123	6-8 weeks	6-8 weeks
25 mg	$211	6-8 weeks	6-8 weeks
50 mg	$323	6-8 weeks	6-8 weeks
100 mg	$545	6-8 weeks	6-8 weeks
200 mg	$817	6-8 weeks	6-8 weeks
500 mg	$1,227	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$121	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.
In vitro	Because GST P1-1 can bind to and inhibit JNK, Ezatiostat hydrochloride has also been exhibited to inhibit GST P1-1, activate JNK, and promote the growth and maturation of hematopoietic progenitors in preclinical models. Moreover, Ezatiostat hydrochloride has been reported to stimulate the proliferation of myeloid precursors. Ezatiostat hydrochloride has been elucidated to induce growth inhibition and cellular apoptosis in human leukemia cells (CC50: 6-17μM). Apart from these, Ezatiostat hydrochloride has shown the stimulation of multilineage differentiation in mature monocytes, granulocytes, and erythrocytes [1][2].
In vivo	Administration of Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/- animals[2].
Synonyms	TLK199 HCl, TER199

Chemical Properties

Molecular Weight	566.11
Formula	C₂₇H₃₆ClN₃O₆S
Cas No.	286942-97-0
Smiles	O=C(OCC)[C@H](C1=CC=CC=C1)NC([C@H](CSCC2=CC=CC=C2)NC(CC[C@@H](C(OCC)=O)N)=O)=O.[H]Cl
Relative Density.	no data available
Sequence	H-γGlu(OEt)-Cys(Bn)-Phg-OEt HCl

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 28.3 mg/mL (49.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7664 mL	8.8322 mL	17.6644 mL	88.3221 mL
5 mM	0.3533 mL	1.7664 mL	3.5329 mL	17.6644 mL
10 mM	0.1766 mL	0.8832 mL	1.7664 mL	8.8322 mL
20 mM	0.0883 mL	0.4416 mL	0.8832 mL	4.4161 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc