Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

DBCO-PEG4-C2-acid

Name: DBCO-PEG4-C2-acid
Brand: TargetMol
SKU: T15070
Rating: 4.5 (1 reviews)

Catalog No. T15070 Copy Product Info

🥰Excellent

DBCO-PEG4-C2-acid is an ADC linker featuring a DBCO group. It enables copper-free click chemistry for conjugating drug payloads to biological targets in drug delivery research.

DBCO-PEG4-C2-acid

Copy Product Info

🥰Excellent

Catalog No. T15070

DBCO-PEG4-C2-acid is an ADC linker featuring a DBCO group. It enables copper-free click chemistry for conjugating drug payloads to biological targets in drug delivery research.

Cas No. 1537170-85-6

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$39	5 days	5 days

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

Product Introduction

Bioactivity

Description	DBCO-PEG4-C2-acid is an ADC linker featuring a DBCO group. It enables copper-free click chemistry for conjugating drug payloads to biological targets in drug delivery research.
In vitro	DBCO-PEG4-C2-acid is a bioorthogonal PROTAC linker that conjugates target proteins and E3 ligases via copper-free click chemistry [1].

Chemical Properties

Molecular Weight	552.62
Formula	C₃₀H₃₆N₂O₈
Cas No.	1537170-85-6
Smiles	O=C(O)CCOCCOCCOCCOCCNC(=O)CCC(=O)N1C=2C=CC=CC2C#CC=3C=CC=CC3C1
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33 mg/mL (59.72 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8096 mL	9.0478 mL	18.0956 mL	90.4781 mL
5 mM	0.3619 mL	1.8096 mL	3.6191 mL	18.0956 mL
10 mM	0.1810 mL	0.9048 mL	1.8096 mL	9.0478 mL
20 mM	0.0905 mL	0.4524 mL	0.9048 mL	4.5239 mL
50 mM	0.0362 mL	0.1810 mL	0.3619 mL	1.8096 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc