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Delavirdine

Name: Delavirdine
Brand: TargetMol
SKU: T7212L
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: U 90152, BHAP-U 90152) Copy Product Info

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Synonyms: U 90152, BHAP-U 90152

Catalog No. T7212L Copy Product Info

Purity: 99.96%

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Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection. It works by non-competitively binding to HIV-1 reverse transcriptase and altering its conformation, thereby inhibiting the reverse transcription of viral RNA into DNA. In vitro, its half-maximal inhibitory concentration (IC₅₀) against HIV-1 reverse transcriptase can be as low as the nanomolar range (0.26 μM).

Cas No. 136817-59-9

Pack Size	Price	USA Stock	Global Stock
5 mg	$32	-	In Stock
10 mg	$53	-	In Stock
25 mg	$67	-	In Stock
50 mg	$74	-	In Stock
1 mL x 10 mM (in DMSO)	$35	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.96%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection. It works by non-competitively binding to HIV-1 reverse transcriptase and altering its conformation, thereby inhibiting the reverse transcription of viral RNA into DNA. In vitro, its half-maximal inhibitory concentration (IC₅₀) against HIV-1 reverse transcriptase can be as low as the nanomolar range (0.26 μM).
Targets & IC50	MT4:160 nM, CCRF-CEM cells:0.11 μM（EC50）, H9 cells:0.4 μM, Hepatocyte cells:0.846 nM, HeLa cells:124 nM, MT4:23 μM（CC50）, MT2:0.01 μM
Synonyms	U 90152, BHAP-U 90152

Chemical Properties

Molecular Weight	456.56
Formula	C₂₂H₂₈N₆O₃S
Cas No.	136817-59-9
Smiles	O=C(C1=CC=2C=C(C=CC2N1)NS(=O)(=O)C)N3CCN(C4=NC=CC=C4NC(C)C)CC3
Relative Density.	1.388g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12.8 mg/mL (28.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1903 mL	10.9515 mL	21.9029 mL	109.5146 mL
5 mM	0.4381 mL	2.1903 mL	4.3806 mL	21.9029 mL
10 mM	0.2190 mL	1.0951 mL	2.1903 mL	10.9515 mL
20 mM	0.1095 mL	0.5476 mL	1.0951 mL	5.4757 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc