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Olaratumab(IMC-3G3) is a human monoclonal IgG1 antibody against platelet-derived growth factor receptor alpha (PDGFRα), which has antitumor effects and can be used to study advanced soft tissue sarcomas.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 372.00 | |
5 mg | In stock | $ 972.00 | |
10 mg | In stock | $ 1,550.00 |
Description | Olaratumab(IMC-3G3) is a human monoclonal IgG1 antibody against platelet-derived growth factor receptor alpha (PDGFRα), which has antitumor effects and can be used to study advanced soft tissue sarcomas. |
In vitro | In SKOV3-ip1 cells, IMC-3G3 (Olaratumab) at a concentration of 100 μg/mL for 72 hours blocked the phosphorylation of PDGFRα. Furthermore, the combination of IMC-3G3 with docetaxel notably induced apoptosis in SKOV3-ip1 and HeyA8 cell lines [1]. |
In vivo | IMC-3G3 ( Olaratumab ) ( i.p., 40 mg / kg, three times per week, 6 weeks ) In SKOV3-ip1 tumor-bearing mice, IMC-3G3 alone had no significant anti-tumor effect compared with the control group. In HeyA8 tumor-bearing mice, IMC-3G3 monotherapy showed a significant anti-tumor effect compared with the control group, with a tumor reduction rate of 62 % [ 1 ]. |
Synonyms | LY3012207, IMC-3G3 |
Molecular Weight | N/A |
CAS No. | 1024603-93-7 |
store at low temperature
store at -80°C
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Olaratumab 1024603-93-7 Angiogenesis Tyrosine Kinase/Adaptors PDGFR LY-3012207 LY3012207 LY 3012207 IMC-3G3 inhibitor inhibit