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Olaratumab (Synonyms: LY3012207, IMC-3G3)
Catalog No. T76761 Copy Product Info
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Olaratumab(IMC-3G3) is a human monoclonal IgG1 antibody against platelet-derived growth factor receptor alpha (PDGFRα), which has antitumor effects and can be used to study advanced soft tissue sarcomas.
Olaratumab
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Catalog No. T76761
Synonyms LY3012207, IMC-3G3
Olaratumab(IMC-3G3) is a human monoclonal IgG1 antibody against platelet-derived growth factor receptor alpha (PDGFRα), which has antitumor effects and can be used to study advanced soft tissue sarcomas.
Olaratumab
Cas No. 1024603-93-7
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | In Stock | In Stock | |
| 5 mg | $645 | In Stock | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,530 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,790 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.7% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Olaratumab(IMC-3G3) is a human monoclonal IgG1 antibody against platelet-derived growth factor receptor alpha (PDGFRα), which has antitumor effects and can be used to study advanced soft tissue sarcomas. |
| In vitro | In SKOV3-ip1 cells, IMC-3G3 (Olaratumab) at a concentration of 100 μg/mL for 72 hours blocked the phosphorylation of PDGFRα. Furthermore, the combination of IMC-3G3 with docetaxel notably induced apoptosis in SKOV3-ip1 and HeyA8 cell lines [1]. |
| In vivo | IMC-3G3 ( Olaratumab ) ( i.p., 40 mg / kg, three times per week, 6 weeks ) In SKOV3-ip1 tumor-bearing mice, IMC-3G3 alone had no significant anti-tumor effect compared with the control group. In HeyA8 tumor-bearing mice, IMC-3G3 monotherapy showed a significant anti-tumor effect compared with the control group, with a tumor reduction rate of 62 % [ 1 ]. |
| Synonyms | LY3012207, IMC-3G3 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | PDGFRA/CD140a |
| Molecular Weight | 147.12 kDa |
| Cas No. | 1024603-93-7 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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