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CDK2-IN-4

Name: CDK2-IN-4
Brand: TargetMol
SKU: T14916
Price: 79 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14916Cas No. 2079895-42-2

CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM.

CDK2-IN-4

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Purity: 99.10%

Catalog No. T14916Cas No. 2079895-42-2

CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$79	In Stock	In Stock
5 mg	$213	In Stock	In Stock
10 mg	$338	In Stock	In Stock
25 mg	$579	In Stock	In Stock
50 mg	$793	-	In Stock
100 mg	$1,130	-	In Stock
1 mL x 10 mM (in DMSO)	$235	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.10%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

CDK2-IN-4 AI Summary

CDK2-IN-4 exhibits bioactivity primarily against cyclin-dependent kinases (CDKs) with varying potencies across different CDK/cyclin complexes. It shows strong inhibition of CDK2/cyclin E and CDK2/cyclin A2, with IC50 values of 31.0 nM and 22.0 nM, respectively. It also inhibits CDK1/cyclin B with an IC50 value of 4300.0 nM, and CDK3/cyclin A2 with an IC50 value of 2870.0 nM. The compound demonstrates weaker inhibitory activity against CDK4/cyclin D1 and CDK9/cyclin T1, with IC50 values greater than 20000.0 nM and 9400.0 nM, respectively. Despite its selective inhibition profile, it does not show significant antiproliferative activity against human A2058 cells but exhibits notable antiproliferative effects against human K562 cells (94.5% activity), MOLM-13 cells (98.3% activity), and MV4-11 cells (62.8% activity) at a concentration of 10 µM using the resazurin assay after 72 hours of incubation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM.
Targets&IC50	CDK1-CyclinB:86 μM (IC50), CDK2-CyclinA:44 nM (IC50)

Chemical Properties

Molecular Weight	442.49
Formula	C₂₃H₁₈N₆O₂S
Cas No.	2079895-42-2
Smiles	NS(=O)(=O)c1ccc(Nc2nc(-c3cccc(c3)-c3ccccc3)c3[nH]cnc3n2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 58 mg/mL (131.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2599 mL	11.2997 mL	22.5994 mL	112.9969 mL
5 mM	0.4520 mL	2.2599 mL	4.5199 mL	22.5994 mL
10 mM	0.2260 mL	1.1300 mL	2.2599 mL	11.2997 mL
20 mM	0.1130 mL	0.5650 mL	1.1300 mL	5.6498 mL
50 mM	0.0452 mL	0.2260 mL	0.4520 mL	2.2599 mL
100 mM	0.0226 mL	0.1130 mL	0.2260 mL	1.1300 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc