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CDK2-IN-4

Name: CDK2-IN-4
Brand: TargetMol
SKU: T14916
Price: 79 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14916Cas No. 2079895-42-2

CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM.

CDK2-IN-4

🥰Excellent

Purity: 99.10%

Catalog No. T14916Cas No. 2079895-42-2

CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM.

Pack Size	Price	Availability
1 mg	$79	In Stock
5 mg	$213	In Stock
10 mg	$338	In Stock
25 mg	$579	In Stock
50 mg	$793	In Stock
100 mg	$1,130	In Stock
1 mL x 10 mM (in DMSO)	$253	In Stock

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Batch Information

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Purity:99.10%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM.
Targets&IC50	CDK2-CyclinA:44 nM (IC50), CDK1-CyclinB:86 μM (IC50)

Chemical Properties

Molecular Weight	442.49
Formula	C₂₃H₁₈N₆O₂S
Cas No.	2079895-42-2
Smiles	NS(=O)(=O)c1ccc(Nc2nc(-c3cccc(c3)-c3ccccc3)c3[nH]cnc3n2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 19.83 mg/mL (44.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2599 mL	11.2997 mL	22.5994 mL	112.9969 mL
5 mM	0.4520 mL	2.2599 mL	4.5199 mL	22.5994 mL
10 mM	0.2260 mL	1.1300 mL	2.2599 mL	11.2997 mL
20 mM	0.1130 mL	0.5650 mL	1.1300 mL	5.6498 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc