TL1A/TNFSF15 Protein, Mouse, Recombinant

Name: TL1A/TNFSF15 Protein, Mouse, Recombinant
Brand: TargetMol
SKU: TMPJ-00603
Rating: 4.5 (1 reviews)

(Synonyms: VEGI, Vascular Endothelial Cell Growth Inhibitor, Tumor Necrosis Factor Ligand Superfamily Member 15, TNFSF15, TNF Ligand-Related Molecule 1, TL1) Copy Product Info

Synonyms: VEGI, Vascular Endothelial Cell Growth Inhibitor, Tumor Necrosis Factor Ligand Superfamily Member 15, TNFSF15, TNF Ligand-Related Molecule 1, TL1

Catalog No. TMPJ-00603 Copy Product Info

Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.

TL1A/TNFSF15 Protein, Mouse, Recombinant

Pack Size	Price	USA Stock	Global Stock
5 µg	$74	7-10 days	7-10 days
10 µg	$118	-	In Stock
20 µg	$187	7-10 days	7-10 days
50 µg	$350	7-10 days	7-10 days
100 µg	$519	7-10 days	7-10 days
200 µg	$779	7-10 days	7-10 days
500 µg	$1,330	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:SDS-PAGE: > 99.9%; SEC-HPLC: 98.84%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1. Loaded TL1A Antibody-Fc on Protein A Biosensor, can bind Mouse TL1A-None with an affinity constant of 12.8 pM as determined in BLI assay. (Regularly tested) 2. Immobilized Recombinant Mouse TL1A at 2μg/ml (100 μl/well) can bind Human TL1A Antibody (9H5). The ED50 of Human TL1A Antibody (9H5) is 1.73 ng/ml. (Regularly tested)
Description	Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
Species	Mouse
Expression System	E. coli
Tag	Tag Free
Accession Number	AAV33431.1
Amino Acid	Ile76-Leu252
Construction	Ile76-Leu252
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 300 mM NaCl, pH 7.0.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	VEGI, Vascular Endothelial Cell Growth Inhibitor, Tumor Necrosis Factor Ligand Superfamily Member 15, TNFSF15, TNF Ligand-Related Molecule 1, TL1
Research Background	Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.

Chemical Properties

Molecular Weight

19 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.