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TL1A Protein, Mouse, Recombinant

Catalog No. TMPJ-00603
Synonyms: TNFSF15, Tumor Necrosis Factor Ligand Superfamily Member 15, VEGI, Vascular Endothelial Cell Growth Inhibitor, TL1, TNF Ligand-Related Molecule 1

Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
TL1A Protein, Mouse, Recombinant
Pack Size Availability Price/USD Quantity
10 μg In stock $ 118.00
50 μg 5 days $ 350.00
500 μg 5 days $ 1,330.00
1 mg 5 days $ 2,970.00
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Biological Description
Technical Params
Product Properties
Biological Information 1. Loaded TL1A Antibody-Fc on Protein A Biosensor, can bind Mouse TL1A-None with an affinity constant of 12.8 pM as determined in BLI assay. (Regularly tested) 2. Immobilized Recombinant Mouse TL1A at 2μg/ml (100 μl/well) can bind Human TL1A Antibody (9H5). The ED50 of Human TL1A Antibody (9H5) is 1.73 ng/ml. (Regularly tested) 

Description Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
Species Mouse
Expression System E. coli
Tag None
Accession Number AAV33431.1
Synonyms TNFSF15, Tumor Necrosis Factor Ligand Superfamily Member 15, VEGI, Vascular Endothelial Cell Growth Inhibitor, TL1, TNF Ligand-Related Molecule 1
Amino Acid Ile76-Leu252
Construction Recombinant Mouse TNF-like 1 is produced by our E.coli expression system and the target gene encoding Ile76-Leu252 is expressed.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)

Molecular Weight 19 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH 7.0.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.

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Keywords

TL1A Protein, Mouse, Recombinant TNFSF15 TNFSF 15 TL 1 Tumor Necrosis Factor Ligand Superfamily Member 15 VEGI TNFSF-15 TL-1 Vascular Endothelial Cell Growth Inhibitor TL1 TNF Ligand-Related Molecule 1 recombinant recombinant-proteins proteins protein

 

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