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Semaglutide TFA

Name: Semaglutide TFA
Brand: TargetMol
SKU: T12878
Price: 380 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12878

Alias Semaglutide TFA (910463-68-2 free base)

Semaglutide TFA is a glucagon-like peptide-1 congener that induces weight loss, lowers blood glucose levels, and reduces cardiovascular risk in diabetic patients.Semaglutide TFA induces mild-to-moderate and transient gastrointestinal disturbances, and may be used in the study of type 2 diabetes and obesity.

Semaglutide TFA

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Purity: 99.94%

Catalog No. T12878Alias Semaglutide TFA (910463-68-2 free base)

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$380	-	In Stock
5 mg	$490	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Potency:/

Appearance:Solid

Color:White

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COA MS HPLC

Product Introduction

Bioactivity

Description	Semaglutide TFA is a glucagon-like peptide-1 congener that induces weight loss, lowers blood glucose levels, and reduces cardiovascular risk in diabetic patients.Semaglutide TFA induces mild-to-moderate and transient gastrointestinal disturbances, and may be used in the study of type 2 diabetes and obesity.
Targets&IC50	GLP1 receptor:0.38 nM (Kd)
In vitro	Semaglutide TFA is a modified GLP-1 analog with two substitutions (Aib and Arg) at amino acids 8 and 34 and a chemical modification of the lysine at position 26 compared to human GLP-1. It has an affinity for the GLP-1 receptor of 0.38 nM. [1] The amino acid sequence of Semaglutide TFA shares 94% homology with human GLP-1. [3]
In vivo	The plasma half-life of Semaglutide TFA was 46 hours after intravenous injection and the mean retention time (MRT) was 63.6 hours after subcutaneous injection in a small pig study.[1] Semaglutide TFA significantly ameliorated dyskinesia induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In addition, it protects dopaminergic neurons in the brain by restoring tyrosine hydroxylase (TH) levels, attenuating inflammatory responses, reducing lipid peroxidation, inhibiting apoptosis and promoting the expression of autophagy-related proteins. Semaglutide TFA shows better results in most aspects compared to liraglutide. [2] Semaglutide TFA lowers blood glucose by promoting insulin secretion and is also effective in reducing body weight. [3]
Synonyms	Semaglutide TFA (910463-68-2 free base)

Chemical Properties

Molecular Weight	4225.6482
Formula	C₁₈₉H₂₉₀F₃N₄₅O₆₁
Smiles	CC[C@@H]([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CC(C)C)=O)Cc(cn1)c2c1cccc2)=O)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@H](O)C)NC(CNC([C@@H](NC(C(C)(NC([C@H](Cc3ncnc3)N)=O)C)=O)CCC(O)=O)=O)=O)=O)Cc4ccccc4)=O)=O)CO)=O)CC(O)=O)=O)=O)CO)=O)CO)=O)Cc5ccc(O)cc5)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)C)=O)C)=O)CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)=O)CCC(O)=O)=O)Cc6ccccc6)=O)C.OC(C(F)(F)F)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (18.93 mM), Sonication is recommended.

DMSO: 80 mg/mL (18.93 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.2367 mL	1.1833 mL	2.3665 mL	11.8325 mL
5 mM	0.0473 mL	0.2367 mL	0.4733 mL	2.3665 mL
10 mM	0.0237 mL	0.1183 mL	0.2367 mL	1.1833 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc