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EIPA hydrochloride

Name: EIPA hydrochloride
Brand: TargetMol
SKU: T11172
Rating: 4.5 (1 reviews)

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Catalog No. T11172Cas No. 1345839-28-2

Alias MH 12-43 hydrochloride, L593754 hydrochloride

EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.

EIPA hydrochloride

Copy Product Info

🥰Excellent

Catalog No. T11172Alias MH 12-43 hydrochloride, L593754 hydrochlorideCas No. 1345839-28-2

EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.

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Product Introduction

Bioactivity

Description	EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.
Targets&IC50	TRPP3 channel:10.5 μM
Synonyms	MH 12-43 hydrochloride, L593754 hydrochloride

Chemical Properties

Molecular Weight	336.22
Formula	C₁₁H₁₉Cl₂N₇O
Cas No.	1345839-28-2
Smiles	Cl.CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (386.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9742 mL	14.8712 mL	29.7424 mL	148.7122 mL
5 mM	0.5948 mL	2.9742 mL	5.9485 mL	29.7424 mL
10 mM	0.2974 mL	1.4871 mL	2.9742 mL	14.8712 mL
20 mM	0.1487 mL	0.7436 mL	1.4871 mL	7.4356 mL
50 mM	0.0595 mL	0.2974 mL	0.5948 mL	2.9742 mL
100 mM	0.0297 mL	0.1487 mL	0.2974 mL	1.4871 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc