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EIPA hydrochloride

Name: EIPA hydrochloride
Brand: TargetMol
SKU: T11172
Rating: 4.5 (1 reviews)

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Catalog No. T11172Cas No. 1345839-28-2

Alias MH 12-43 hydrochloride, L593754 hydrochloride

EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.

EIPA hydrochloride

🥰Excellent

Catalog No. T11172Alias MH 12-43 hydrochloride, L593754 hydrochlorideCas No. 1345839-28-2

EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.

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Product Introduction

Bioactivity

Description	EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.
Targets&IC50	TRPP3 channel:10.5 μM
Synonyms	MH 12-43 hydrochloride, L593754 hydrochloride

Chemical Properties

Molecular Weight	336.22
Formula	C₁₁H₁₉Cl₂N₇O
Cas No.	1345839-28-2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (386.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9742 mL	14.8712 mL	29.7424 mL	148.7122 mL
5 mM	0.5948 mL	2.9742 mL	5.9485 mL	29.7424 mL
10 mM	0.2974 mL	1.4871 mL	2.9742 mL	14.8712 mL
20 mM	0.1487 mL	0.7436 mL	1.4871 mL	7.4356 mL
50 mM	0.0595 mL	0.2974 mL	0.5948 mL	2.9742 mL
100 mM	0.0297 mL	0.1487 mL	0.2974 mL	1.4871 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc