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Emapalumab
(Synonyms: NI-0501) Copy Product Info
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Synonyms: NI-0501
Catalog No. T76742 Copy Product Info
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Emapalumab (NI-0501) is an IgG1 monoclonal antibody that humanizes human monoclonal antibodies against interferon gamma, blocking its binding to cell surface receptors and activating inflammatory signaling. Emapalumab has a high binding force (Kd=1.4 pM) to free IFN-γ and to IFN-γ bound to its receptor. Emapalumab can be used in the study of hemophagocytic lymphohistiocytosis (HLH).
Cas No. 1709815-23-5
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $179 | In Stock | In Stock | |
| 5 mg | $546 | - | In Stock | |
| 10 mg | $891 | - | In Stock | |
| 25 mg | $1,370 | - | In Stock | |
| 50 mg | $1,830 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.56% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
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Chemical Properties
Antibody Information
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| Description | Emapalumab (NI-0501) is an IgG1 monoclonal antibody that humanizes human monoclonal antibodies against interferon gamma, blocking its binding to cell surface receptors and activating inflammatory signaling. Emapalumab has a high binding force (Kd=1.4 pM) to free IFN-γ and to IFN-γ bound to its receptor. Emapalumab can be used in the study of hemophagocytic lymphohistiocytosis (HLH). |
| In vitro | Impaired by Emapalumab (NI-0501) is the interaction between IFNcR1 and IFNc-Receptor-2 (IFNcR2) induced by IFNc at the cell surface. |
| Endotoxin | <1.0 EU/mg |
| Synonyms | NI-0501 |
| Reactivity | Human |
| Verified Activity | Immobilized Human IFN gamma Protein (TMPY-01714) at 8 μg/mL (100 μL/well) can bind Emapalumab. The EC50 is 3.64 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IFNg |
| Molecular Weight | 145.22 kDa |
| Cas No. | 1709815-23-5 |
| Isotype | Human IgG1 lambda C2 |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Emapalumab chemical structure | Emapalumab in vitro | Emapalumab molecular weight
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