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DSP-0565

Name: DSP-0565
Brand: TargetMol
SKU: T11106
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11106Cas No. 1226855-28-2

Alias 2-(2'-fluorobiphenyl-2-yl)acetamide

DSP-0565 exhibits anti-convulsant activity and good safety margin in various models including scPTZ, 6 Hz, MES, and amygdala kindling. DSP-0565 can be used in studies about acting as a broad-spectrum anti-epileptic drug.

DSP-0565

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Purity: 99.56%

Catalog No. T11106Alias 2-(2'-fluorobiphenyl-2-yl)acetamideCas No. 1226855-28-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	In Stock	In Stock
2 mg	$175	In Stock	In Stock
5 mg	$268	In Stock	In Stock
10 mg	$394	In Stock	In Stock
25 mg	$592	In Stock	In Stock
50 mg	$828	In Stock	In Stock
100 mg	$1,130	In Stock	In Stock
500 mg	$2,260	-	In Stock
1 mL x 10 mM (in DMSO)	$232	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

DSP-0565 AI Summary

DSP-0565 has demonstrated stability in both rat and human hepatic microsomes, retaining more than 95.0% of its concentration after 30 minutes in the presence of NADPH. Bioactivity studies reveal its anticonvulsant properties in amygdala kindling rat models, where it increases the after discharge threshold at 50 mg/kg and 100 mg/kg doses while decreasing after discharge duration. In mouse models, it has shown anticonvulsant activity in both po dosed maximal electroshock and pentylenetetrazole-induced seizure models, with ED50 values of 27.0 mg/kg. Additionally, in the 6-Hz induced seizure mouse model, the ED50 was recorded at 56.0 mg/kg. Neurotoxicity was observed in po dosed mice with a TD50 value of 129.0 mg/kg, resulting in a therapeutic index of 4.8 for the maximal electroshock model and 2.3 for the 6-Hz model. The unbound brain concentration in mice at a 30 mg/kg dose was determined to be 24.6 umol/L..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	DSP-0565 exhibits anti-convulsant activity and good safety margin in various models including scPTZ, 6 Hz, MES, and amygdala kindling. DSP-0565 can be used in studies about acting as a broad-spectrum anti-epileptic drug.
Synonyms	2-(2'-fluorobiphenyl-2-yl)acetamide

Chemical Properties

Molecular Weight	229.25
Formula	C₁₄H₁₂FNO
Cas No.	1226855-28-2
Smiles	C(C(N)=O)C1=C(C=CC=C1)C2=C(F)C=CC=C2
Relative Density.	1.190 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (196.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3621 mL	21.8103 mL	43.6205 mL	218.1025 mL
5 mM	0.8724 mL	4.3621 mL	8.7241 mL	43.6205 mL
10 mM	0.4362 mL	2.1810 mL	4.3621 mL	21.8103 mL
20 mM	0.2181 mL	1.0905 mL	2.1810 mL	10.9051 mL
50 mM	0.0872 mL	0.4362 mL	0.8724 mL	4.3621 mL
100 mM	0.0436 mL	0.2181 mL	0.4362 mL	2.1810 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc