ANXA1 Protein, Cynomolgus, Recombinant (His)

Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activities in an apoA-I- or ANXA1-dependent manner. The latter activity occurs by mediating the efflux of ANXA1, which plays a critical role in anti-inflammatory effects, cholesterol transport, exosome and microparticle secretion, and apoptotic cell clearance.

Pack Size	Availability	Price/USD
100 μg	5 days	$ 534.00
500 μg	5 days	$ 2,140.00
1 mg	5 days	$ 3,570.00

Pack Size

Availability

Price/USD

Quantity

100 μg

5 days

$ 534.00

500 μg

5 days

$ 2,140.00

1 mg

5 days

$ 3,570.00

Description

Species	Cynomolgus
Expression System	E. coli
Tag	C-His
Accession Number	A0A2K5W030
Synonyms	Lipocortin I, Calpactin-2, ANX1, ANXA1, Annexin A1, Annexin I, LPC1, Calpactin II, p35, Annexin-1, Chromobindin-9
Construction	Recombinant Cynomolgus ANXA1 Protein is expressed from E.coli with His tag at the C-Terminus. It contains Ala2-Asn346.[Accession \|XP_005581995.1]
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	The protein has a predicted MW of 39.69 kDa same as Tris-Bis PAGE result.

Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability & Storage	-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activities in an apoA-I- or ANXA1-dependent manner. The latter activity occurs by mediating the efflux of ANXA1, which plays a critical role in anti-inflammatory effects, cholesterol transport, exosome and microparticle secretion, and apoptotic cell clearance.