Compound Libraries

Compound Libraries

A compound library or chemical library is a collection of stored chemicals usually used ultimately in high-throughput screening or industrial manufacture. Depending upon their scope (specific goal or diverse oriented goal) and design (chemical space or scaffold), our compound libraries can be classified as Focused Bioactive Libraries, Natural Product Libraries, Fragment Libraries, and Diversity Sets. These libraries have been extensively validated in our in- house biological assays and widely employed by research institutions and pharmaceutical companies in complementary screening strategies. Identifying novel and robust chemical starting points remains one of the biggest challenges in drug discovery today. Over the last decade, it has been common practice during the early stage of a project to screen vast numbers of compounds that cover larger section of chemical space evenly (diversity-led paradigm) in high-throughput assays in order to identify those chemicals which have the potential to modulate the target of interest. The costly nature of such mass screening, the consequent need to use reductionist assays that are optimized primarily for scale and speed, and the increasing realization that drug property space is far from random has more recently led to the use of smaller, higher quality screening collections (target-led approaches). All of these compound libraries and their screening approaches have their own particular advantages and disadvantages.
Compound Library Categories:
Focused Bioactive Libraries Natural Product Libraries Drug-like Compound Library Fragment Libraries

Focused Bioactive Libraries

Generally higher hit rates are observed in screening focused bioactive libraries when compared with the screening of diverse sets, and the hit clusters obtained from a successful focused library screening campaign usually exhibit discernable structure-activity relationships that facilitate follow up of these hits. Focused Bioactive Libraries is a powerful tool for drug screening, cell induction, drug repurposing, mechanism research, target identification, positive control and other related research fields.

Antiviral Annotated Library CNS Annotated Library Opportunistic Pathogens of Immunocompromised Hosts Annotated Library Anti-Viral Compound Library Anti-COVID-19 Compound Library Anti-COVID-19 Compound Library (CADD) 3CLpro-Targeted Compound Library (CADD) ACE2-Targeted Compound Library (CADD) RBD-Targeted Compound Library (CADD) Nsp16-Targeted Compound Library (CADD) PLpro-Targeted Compound Library (CADD) RdRP-Targeted Compound Library (CADD) X Domain-Targeted Compound Library (CADD) Nsp15-Targeted Compound Library (CADD) Anti-Infection Compound Library Anti-Diabetic Compound Library Anti-Cancer Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Metabolism Compound Library Cancer Cell Differentiation Compound Library Anti-Cancer Drug Library Chemotherapy Drug Library Targeted Therapy Drug Library Anti-Cancer Active Compound Library Immuno-Oncology Compound Library Anti-Cancer Compound Library Plus Anti-Lung Cancer Compound Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Fungal Compound Library Anti-Parasitic Compound Library Anti-Bacterial Compound Library Anti-Nervous System Disease Library Immunology/Inflammation Compound Library Nonsteroidal Anti-Inflammatory Compound Library Anti-Metabolism Disease Compound Library Anti-Cardiovascular Disease Compound Library Anti-Obesity Compound Library Anti-Hypertension Compound Library Hematonosis Compound Library Anti-Fibrosis Compound Library Anti-Parkinson's Disease Compound Library

Natural Product Libraries

Natural products are an unsurpassed source of chemical diversity and an ideal starting point for any screening program for pharmacologically active small molecules. Historically, natural products have been the most successful source of new drugs. Natural Product Libraries is a powerful tool for cell induction research and the drug screening focused on unique natural structures along with new bioactivity.

Natural Product Library for HTS Selectable Natural Product Library

Drug-like Compound Library

Golden Scaffold Library Mini Scaffold Library Pre-plated Diversity Sets

Fragment Libraries

Fragment-based drug discovery (FBDD) has emerged in the past decade as an alternative approach to traditional lead identification via high-throughput screening (HTS). Unlike HTS, FBDD identifies smaller compounds, the “fragments,” which bind to different parts of a biological target. FBDD has played a role in discovery of 2 approved drugs and at least 30 drugs that are in various stages of clinical development. In response to this evident trend in drug discovery, TargetMol has designed its Fragment Libraries, including a selection of unique fragment subsets: Drug-Fragment Library, High Solubility Fragment Library, and Featured Fragment Library.

Drug-fragment Library Featured Fragment Library High Solubility Fragment Library