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TL13-22

Name: TL13-22
Brand: TargetMol
SKU: T37084
Price: 329 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37084Cas No. 2229036-65-9

Alias TL 13-22

TL13-22 is a potent inhibitor of Anaplastic Lymphoma Kinase (ALK) with an IC₅₀ value of 0.54 nM and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 (induces ALK protein degradation) as a negative control.TL13-22 also induces degradation of other kinases, including Aurora A, FER, PTK2, and RPS6KA1.

TL13-22

🥰Excellent

Purity: 99.13%

Catalog No. T37084Alias TL 13-22Cas No. 2229036-65-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$329	-	In Stock
5 mg	$826	-	In Stock
10 mg	$1,090	-	In Stock
25 mg	$1,650	-	In Stock
50 mg	$2,230	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.13%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	TL13-22 is a potent inhibitor of Anaplastic Lymphoma Kinase (ALK) with an IC₅₀ value of 0.54 nM and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 (induces ALK protein degradation) as a negative control.TL13-22 also induces degradation of other kinases, including Aurora A, FER, PTK2, and RPS6KA1.
Targets&IC50	ALK:0.54 nM
In vitro	TL13-22 prompted the concentrations of Aurora A, FER, PTK2 and RPS6KA1 kinase reduction at 11.3, 5.74, 18.4 and 65.9 nM, respectively. [1]
Synonyms	TL 13-22

Chemical Properties

Molecular Weight	947.5
Formula	C₄₅H₅₅ClN₁₀O₉S
Cas No.	2229036-65-9
Smiles	O=C1C=2C=CC=C(NCC(=O)NCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C(Cl)C(=N5)NC=6C=CC=CC6S(=O)(=O)C(C)C)C(OC)=C4)CC3)C2C(=O)N1C7C(=O)NCCC7

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (211.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0554 mL	5.2770 mL	10.5541 mL	52.7704 mL
5 mM	0.2111 mL	1.0554 mL	2.1108 mL	10.5541 mL
10 mM	0.1055 mL	0.5277 mL	1.0554 mL	5.2770 mL
20 mM	0.0528 mL	0.2639 mL	0.5277 mL	2.6385 mL
50 mM	0.0211 mL	0.1055 mL	0.2111 mL	1.0554 mL
100 mM	0.0106 mL	0.0528 mL	0.1055 mL	0.5277 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc