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Milbemycin A4

Name: Milbemycin A4
Brand: TargetMol
SKU: TN7268
Price: 347 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Milbemycin α3, Antibiotic B 41A4) Copy Product Info

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Synonyms: Milbemycin α3, Antibiotic B 41A4

Catalog No. TN7268 Copy Product Info

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Milbemycin A4, a distinguished member of the macrocyclic lactones family featuring a unique spiroketal group, is derived from the fermentation of the soil bacterium Streptomyces hygroscopicus subsp. aureolacrimosus. Milbemycin A4 acts by enhancing the opening of glutamate and GABA-gated chloride channels, rendering it effective as both a nematocide and insecticide.

Cas No. 51596-11-3

Pack Size	Price	USA Stock	Global Stock
1 mg	$347	-	In Stock
5 mg	$768	-	In Stock
10 mg	$1,160	-	In Stock
25 mg	$1,720	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Milbemycin A4, a distinguished member of the macrocyclic lactones family featuring a unique spiroketal group, is derived from the fermentation of the soil bacterium Streptomyces hygroscopicus subsp. aureolacrimosus. Milbemycin A4 acts by enhancing the opening of glutamate and GABA-gated chloride channels, rendering it effective as both a nematocide and insecticide.
Synonyms	Milbemycin α3, Antibiotic B 41A4

Chemical Properties

Molecular Weight	542.71
Formula	C₃₂H₄₆O₇
Cas No.	51596-11-3
Smiles	C[C@H](C/C(C)=C/C[C@]1([H])C[C@]([H])(O2)C[C@]3(CC[C@H](C)[C@@H](CC)O3)O1)/C=C\C=C(CO4)/[C@@]([C@@]4([H])[C@H](O)C(C)=C5)(O)[C@]5([H])C2=O

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (147.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8426 mL	9.2130 mL	18.4260 mL	92.1302 mL
5 mM	0.3685 mL	1.8426 mL	3.6852 mL	18.4260 mL
10 mM	0.1843 mL	0.9213 mL	1.8426 mL	9.2130 mL
20 mM	0.0921 mL	0.4607 mL	0.9213 mL	4.6065 mL
50 mM	0.0369 mL	0.1843 mL	0.3685 mL	1.8426 mL
100 mM	0.0184 mL	0.0921 mL	0.1843 mL	0.9213 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: Milbemycin A4 chemical structure | Milbemycin A4 formula | Milbemycin A4 molecular weight