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Tarlatamab
(Synonyms: AMG-757, AMG757) Copy Product Info
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Synonyms: AMG-757, AMG757
Catalog No. T76986 Copy Product Info
Purity: 95%
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Tarlatamab (AMG-757) is a bispecific T cell engager (BiTE) antibody targeting DLL3 and CD3, with human DLL3 and CD3 KD = 0.64 nM/14.9 nM, for use in immuno-oncology therapy of small cell lung cancer (SCLC).
Tarlatamab
Cas No. 2307488-83-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $619 | - | In Stock | |
| 5 mg | $1,590 | - | In Stock | |
| 10 mg | $2,590 | 2-4 weeks | 2-4 weeks | |
| 25 mg | $4,270 | 2-4 weeks | 2-4 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95%
Appearance:Liquid
Color:Transparent
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Product Introduction
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| Description | Tarlatamab (AMG-757) is a bispecific T cell engager (BiTE) antibody targeting DLL3 and CD3, with human DLL3 and CD3 KD = 0.64 nM/14.9 nM, for use in immuno-oncology therapy of small cell lung cancer (SCLC). |
| Targets & IC50 | DLL3 (human):0.64 nM （Kd), CD3 (human):14.9 nM (Kd) |
| In vitro | Tarlatamab (0-10 nM; 48 h) exhibits specific cytotoxicity toward DLL3-expressing SCLC cell lines [1]. Tarlatamab (0-10 nM; 4-72 h) increases granzyme B levels and cytotoxicity in a time-dependent manner, with maximal signaling observed at 48 h. T-cell activation or inflammatory markers CD69, CD71, PD-1, and PD-L1 (37-39) were upregulated[1]. |
| In vivo | Tarlatamab (3 mg/kg; intraperitoneal administration; once weekly; for three consecutive weeks) demonstrated tumor regression in a small cell lung cancer (SCLC) mouse model [1]. Tarlatamab (12 μg/kg; intraperitoneal administration; single dose) exhibited a mean half-life of 234 hours, mean clearance of 0.487 mL/hour/kg, and steady-state volume of distribution of 146 mL/kg in non-human primates (NHPs) [1]. |
| Synonyms | AMG-757, AMG757 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Target | DLL3 & CD3 |
| Cas No. | 2307488-83-9 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Tarlatamab in vivo | Tarlatamab in vitro
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