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D-myo-Inositol-1,4,5-triphosphate trisodium (Inositol 1,4,5-trisphosphate trisodium) is a second messenger produced in cells by the phospholipase C-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate. It binds to Ins(1,4,5)P3 receptors, resulting in the opening of calcium channels and an increase in intracellular calcium.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 μg | $159 | 35 days | 35 days | |
| 5 mg | $1,230 | 35 days | 35 days |
| Description | D-myo-Inositol-1,4,5-triphosphate trisodium (Inositol 1,4,5-trisphosphate trisodium) is a second messenger produced in cells by the phospholipase C-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate. It binds to Ins(1,4,5)P3 receptors, resulting in the opening of calcium channels and an increase in intracellular calcium. |
| In vitro | The dissociation constant (KD) for D-myo-Inositol-1,4,5-trisphosphate (As an inositol phosphate derivative) complexed with Pr55Gag is 2170 μM. The binding affinities of D-myo-Inositol-1,4,5-trisphosphate for matrix (MA) with KD=568 μM.[4] |
| Synonyms | Ins(1,4,5)-P3 trisodium, Ins(1,4,5)P3, Inositol 1,4,5-trisphosphate trisodium, D-myo-Inositol-1,4,5-triphosphate (sodium salt) |
| Molecular Weight | 489.06 |
| Formula | C6H15Na3O15P3 |
| Cas No. | 141611-10-1 |
| Smiles | O=P(O)(O)O[C@H]1[C@@H]([C@H]([C@H]([C@H]([C@@H]1O)OP(O)(O)=O)O)O)OP(O)(O)=O.[Na].[Na].[Na] |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | PBS (pH 7.2): 50 mg/mL (102.24 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
PBS (pH 7.2)
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Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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