Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BPHA (MMP-2/MMP-9 Inhibitor II) is a potent, selective and orally active inhibitor of MMP-2, MMP-9 and MMP-14 with IC50s of 12 nM, 16 nM and 17 nM, respectively.BPHA does not inhibit MMP-1, -3 and -7 (IC50s of 974, <1000 and 795 nM, respectively).BPHA has anti-angiogenic and BPHA has anti-angiogenic and anti-tumor activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 215.00 | |
5 mg | In stock | $ 593.00 | |
10 mg | In stock | $ 848.00 | |
25 mg | In stock | $ 1,290.00 | |
50 mg | In stock | $ 1,730.00 | |
100 mg | In stock | $ 2,330.00 | |
500 mg | In stock | $ 4,690.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 611.00 |
Description | BPHA (MMP-2/MMP-9 Inhibitor II) is a potent, selective and orally active inhibitor of MMP-2, MMP-9 and MMP-14 with IC50s of 12 nM, 16 nM and 17 nM, respectively.BPHA does not inhibit MMP-1, -3 and -7 (IC50s of 974, >1000 and 795 nM, respectively).BPHA has anti-angiogenic and BPHA has anti-angiogenic and anti-tumor activities. |
Targets&IC50 | MMP2:12 nM, MMP9:16 nM, MMP14:17 nM, MMP1:974 nM, MMP3:>1000 nM, MMP7:795 nM |
In vivo | Administration of BPHA (200 mg/kg; via oral; daily) in mice effectively suppresses tumor-induced angiogenesis, primary tumor growth, and liver metastasis. BPHA exhibits remarkable growth inhibitory activity of 48% and 45% in the B16-BL6 melanoma and F2 hemangio-endothelioma models, respectively.[1] |
Synonyms | MMP-2/MMP-9 Inhibitor II |
Molecular Weight | 396.46 |
Formula | C21H20N2O4S |
CAS No. | 193807-60-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methanol: 22.5 mg/mL (56.8 mM)
DMSO: 90.0 mg/mL (227.0 mM)
You can also refer to dose conversion for different animals. More
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BPHA 193807-60-2 Proteases/Proteasome MMP MMP-2/MMP-9 Inhibitor II inhibitor inhibit