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Anti-MTLC Polyclonal Antibody (Synonyms: MYCT1, MYCT 1 protein, Myc target protein 1, Myc target in myeloid c...)
Catalog No. TMAB-01175 Copy Product Info
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Anti-MTLC Polyclonal Antibody is a Rabbit antibody targeting MTLC. Anti-MTLC Polyclonal Antibody can be used in IF,IHC-Fr,WB.
Anti-MTLC Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-01175
Synonyms MYCT1, MYCT 1 protein, Myc target protein 1, Myc target in myeloid cells protein 1, Myc target 1, Mt-Mc1, MTMC1, MTLC, MGC156310, MGC156309, FLJ21269, AI642973, AI225941, 1110020B04Rik
Anti-MTLC Polyclonal Antibody is a Rabbit antibody targeting MTLC. Anti-MTLC Polyclonal Antibody can be used in IF,IHC-Fr,WB.
Anti-MTLC Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Bioactivity
Antigen Details
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| Description | Anti-MTLC Polyclonal Antibody is a Rabbit antibody targeting MTLC. Anti-MTLC Polyclonal Antibody can be used in IF,IHC-Fr,WB. |
| Synonyms | MYCT1, MYCT 1 protein, Myc target protein 1, Myc target in myeloid cells protein 1, Myc target 1, Mt-Mc1, MTMC1, MTLC, MGC156310, MGC156309, FLJ21269, AI642973, AI225941, 1110020B04Rik |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Dog) |
| Verified Activity | Sample: Brain (Mouse) Lysate at 40 μg Primary: Anti-MTLC (TMAB-01175) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/10000 dilution Predicted band size: 27 kDa Observed band size: 31 kDa  |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Note=Expressed in nuclei of hepatocellular carcinoma cell line Bel7402 cells. |
| Tissue Specificity | Down-regulated in gastric cancer tissues. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | MTLC is a 235 amino acid nuclear protein that is thought to regulate certain myc target genes. Downregulated in gastric cancer tissues, MTLC is expressed in the hepatocellular carcinoma cell line, Bel7402. Overexpression of MTLC is thought to influence tumorigenic conversion, promotion of apoptosis genomic instability and inhibition of hematopoietic differentiation. The gene encoding MTLC maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. |
| Immunogen | KLH conjugated synthetic peptide: human MTLC |
| Antigen Species | Human |
| Gene Name | MYCT1 |
| Gene ID | |
| Protein Name | Myc target protein 1 |
| Uniprot ID | |
| Biology Area | Transcription Factors |
| Function | May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation. |
| Molecular Weight | Theoretical: 27 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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