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8-Hydroxy-DPAT hydrobromide

Name: 8-Hydroxy-DPAT hydrobromide
Brand: TargetMol
SKU: T22534
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22534Cas No. 76135-31-4

Alias 8-OH-DPAT hydrobromide

8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has a selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site.

8-Hydroxy-DPAT hydrobromide

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Purity: 99.99%

Catalog No. T22534Alias 8-OH-DPAT hydrobromideCas No. 76135-31-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$139	In Stock	In Stock
50 mg	$255	In Stock	In Stock
100 mg	$455	In Stock	In Stock
500 mg	$987	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.99%

Appearance:Solid

Color:White to Gray

Resource Download

COA HNMR LCMS

Product Introduction

8-Hydroxy-DPAT hydrobromide AI Summary

8-Hydroxy-DPAT hydrobromide exhibits high binding affinity at the 5-hydroxytryptamine 1A receptor, displacing [3H]8-OH-DPAT in rat brain with a Ki value of 3.18 nM, and shows potent dose-dependent effects with an ED50 value of 0.00006 mg/kg for reducing 5-HTP formation in the rat brain's limbic and striatal regions. It induces hypothermia in both Albino Swiss and CD1 mice with notable dose-dependent effects over various time points and displays antidepressant-like activity by reducing immobility time in the forced swimming test. The hypothermic effect is partially counteracted by the 5-HT1A antagonist WAY 100635. Additionally, the compound shows anxiolytic properties in Sprague-Dawley rats, increasing time spent in the open arm of the Elevated Plus Maze (EPM) test at a dose of 0.5 mg/kg. 8-Hydroxy-DPAT hydrobromide is a potent inhibitor of Bloom's syndrome helicase (BLM) with a potency of 223.9 nM and histone lysine methyltransferase G9a with a potency of 22.4 nM. It also serves as a moderate inhibitor of glutaminase (GLS) with a potency of 11220.2 nM and shows activity against Marburg Virus entry with a potency of 35481.3 nM. Despite showing some activity as an agonist of the mouse serotonin receptor 2A, it demonstrates antiviral activity against SARS-CoV-2 by inhibiting cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 µM and by inhibiting SARS-CoV-2 3CL-Pro protease by 13.03% at 20 µM. In pharmacokinetics, 8-Hydroxy-DPAT hydrobromide has a half-life of 0.45 hours in Sprague-Dawley rat plasma when administered orally at a dose of 10 mg/kg..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has a selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site.
Synonyms	8-OH-DPAT hydrobromide

Chemical Properties

Molecular Weight	328.29
Formula	C₁₆H₂₆BrNO
Cas No.	76135-31-4
Smiles	Br.CCCN(CCC)C1CCc2cccc(O)c2C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Soluble

DMSO: 50 mg/mL (152.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0461 mL	15.2304 mL	30.4609 mL	152.3044 mL
5 mM	0.6092 mL	3.0461 mL	6.0922 mL	30.4609 mL
10 mM	0.3046 mL	1.5230 mL	3.0461 mL	15.2304 mL
20 mM	0.1523 mL	0.7615 mL	1.5230 mL	7.6152 mL
50 mM	0.0609 mL	0.3046 mL	0.6092 mL	3.0461 mL
100 mM	0.0305 mL	0.1523 mL	0.3046 mL	1.5230 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc