keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
α-Conotoxin BuIA is a paralytic peptide neurotoxin that acts as a competitive antagonist of nicotinic acetylcholine receptors (nAChR), with inhibitory concentration 50 (IC50) values of 0.258 nM for α6/α3β2, 1.54 nM for α6/α3β4, and 5.72 nM for α3β2. It serves to differentiate between nAChRs containing the β2- and β4-subunits. Furthermore, α-Conotoxin BuIA selectively inhibits αxβ2 nAChRs, exhibiting a potency hierarchy of α6<α3<α2<α4 [1].
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Description | α-Conotoxin BuIA is a paralytic peptide neurotoxin that acts as a competitive antagonist of nicotinic acetylcholine receptors (nAChR), with inhibitory concentration 50 (IC50) values of 0.258 nM for α6/α3β2, 1.54 nM for α6/α3β4, and 5.72 nM for α3β2. It serves to differentiate between nAChRs containing the β2- and β4-subunits. Furthermore, α-Conotoxin BuIA selectively inhibits αxβ2 nAChRs, exhibiting a potency hierarchy of α6>α3>α2>α4 [1]. |
Molecular Weight | 1311.57 |
Formula | C54H82N14O16S4 |
CAS No. | 846539-62-6 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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α-Conotoxin BuIA 846539-62-6 inhibitor inhibit