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MS 15203

Name: MS 15203
Brand: TargetMol
SKU: T37131
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37131Cas No. 73912-52-4

Alias MS-0015203, MS0015203

MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice.

MS 15203

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Purity: 99.53%

Catalog No. T37131Alias MS-0015203, MS0015203Cas No. 73912-52-4

MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	-	In Stock
5 mg	$60	-	In Stock
10 mg	$106	-	In Stock
25 mg	$222	-	In Stock
50 mg	$328	-	In Stock
100 mg	$492	-	In Stock
500 mg	$1,070	-	In Stock
1 mL x 10 mM (in DMSO)	$68	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.53%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice.
Targets&IC50	b-LEN:80 ± 1 nM
In vitro	To assess the selectivity of MS 15203 for GPR171, screened the ligand against a panel of 80 different transmembrane and soluble receptors, including ~70 GPCRs. MS 15203 dose-dependently displaced radiolabeled b-LEN from hypothalamic membranes with an affinity that was lower than that of b-LEN. IC50 = 80 ± 1 (nM). [1]
In vivo	To examine the effects of long-term activation of GPR171, administered MS 15203 (2.5 mg/kg) to mice by intraperitoneal injection every third day and fed a high-fat diet to exacerbate the effects of the compound. Knockdown of GPR171 in the hypothalamus significantly at tenuated MS 15203-induced weight gain, implying that chronic administration of MS 15203 affects body weight through GPR171. [1]
Synonyms	MS-0015203, MS0015203

Chemical Properties

Molecular Weight	249.22
Formula	C₁₂H₁₁NO₅
Cas No.	73912-52-4
Smiles	O=C(O)C1=CC(=CC(=C1)C(=O)O)NC(=O)C(=C)C

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (160.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0125 mL	20.0626 mL	40.1252 mL	200.6260 mL
5 mM	0.8025 mL	4.0125 mL	8.0250 mL	40.1252 mL
10 mM	0.4013 mL	2.0063 mL	4.0125 mL	20.0626 mL
20 mM	0.2006 mL	1.0031 mL	2.0063 mL	10.0313 mL
50 mM	0.0803 mL	0.4013 mL	0.8025 mL	4.0125 mL
100 mM	0.0401 mL	0.2006 mL	0.4013 mL	2.0063 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc