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Apiin

Name: Apiin
Brand: TargetMol
SKU: T5S1989
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S1989Cas No. 26544-34-3

Alias Apioside

1. Apiin (Apioside) is the reducing and stabilizing agent. 2. Apiin has inhibitory activity in-vitro on iNOS expression and nitrite production when added before LPS stimulation in the medium of J774.A1 cells.

Apiin

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Purity: 99.88%

Catalog No. T5S1989Alias ApiosideCas No. 26544-34-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$222	In Stock	In Stock
25 mg	$355	In Stock	In Stock
50 mg	$496	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$188	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Apiin AI Summary

Apiin demonstrates a range of biological activities. It shows anti-inflammatory activity against mouse RAW264.7 cells by inhibiting LPS-induced nitrite accumulation, with an IC50 value of > 20,000.0 nM, indicating a relatively weak effect. It is an inhibitor targeting the Menin-MLL interaction in MLL-related leukemias, and also inhibits AmpC Beta-Lactamase, BAZ2B, and delayed death in the malarial parasite plastid. Additionally, it induces DNA re-replication in SW480 colon adenocarcinoma cells and inhibits MBNL1-poly(CUG) RNA binding. Apiin inhibits sodium fluorescein uptake in OATP1B1-transfected CHO cells by 69.17% and in OATP1B3-transfected CHO cells by 141.47% at a 10 µM concentration. Furthermore, it inhibits the human PD1/PDL1 interaction with an IC50 value of greater than 100,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Apiin (Apioside) is the reducing and stabilizing agent. 2. Apiin has inhibitory activity in-vitro on iNOS expression and nitrite production when added before LPS stimulation in the medium of J774.A1 cells.
Synonyms	Apioside

Chemical Properties

Molecular Weight	564.49
Formula	C₂₆H₂₈O₁₄
Cas No.	26544-34-3
Smiles	OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)cc2)[C@H](O[C@@H]2OC[C@](O)(CO)[C@H]2O)[C@@H](O)[C@@H]1O
Relative Density.	1.74 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Pyridine, Methanol, etc.: Soluble

Ethanol: Soluble

DMSO: 55 mg/mL (97.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7715 mL	8.8576 mL	17.7151 mL	88.5755 mL
5 mM	0.3543 mL	1.7715 mL	3.5430 mL	17.7151 mL
10 mM	0.1772 mL	0.8858 mL	1.7715 mL	8.8576 mL
20 mM	0.0886 mL	0.4429 mL	0.8858 mL	4.4288 mL
50 mM	0.0354 mL	0.1772 mL	0.3543 mL	1.7715 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc