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2-Iodomelatonin

Name: 2-Iodomelatonin
Brand: TargetMol
SKU: T10073
Price: 297 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10073Cas No. 93515-00-5

2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, exhibiting over 5-fold selectivity for MT1 compared to MT2. It can be used to identify, characterize, and localize melatonin binding sites in the brain and peripheral tissues.

2-Iodomelatonin

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Purity: 99.7%

Catalog No. T10073Cas No. 93515-00-5

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$38	In Stock	-
25 mg	$76	In Stock	-
50 mg	$127	In Stock	-
100 mg	$198	6-8 weeks	6-8 weeks
200 mg	$297	6-8 weeks	6-8 weeks
500 mg	Preferential	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.7%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, exhibiting over 5-fold selectivity for MT1 compared to MT2. It can be used to identify, characterize, and localize melatonin binding sites in the brain and peripheral tissues.
In vitro	2-iodomelatonin (0-7.5 μM; 18 hours) shares the protective properties of melatonin, inhibiting cell death and the increase in Rip2 expression in stressed mutant htt ST14A cells[1].

Chemical Properties

Molecular Weight	358.17
Formula	C₁₃H₁₅IN₂O₂
Cas No.	93515-00-5
Smiles	COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (153.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7920 mL	13.9599 mL	27.9197 mL	139.5985 mL
5 mM	0.5584 mL	2.7920 mL	5.5839 mL	27.9197 mL
10 mM	0.2792 mL	1.3960 mL	2.7920 mL	13.9599 mL
20 mM	0.1396 mL	0.6980 mL	1.3960 mL	6.9799 mL
50 mM	0.0558 mL	0.2792 mL	0.5584 mL	2.7920 mL
100 mM	0.0279 mL	0.1396 mL	0.2792 mL	1.3960 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc