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NH2-C5-NH-Boc

Name: NH2-C5-NH-Boc
Brand: TargetMol
SKU: T18617
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18617Cas No. 51644-96-3

Alias PROTAC Linker 23

NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs.

NH2-C5-NH-Boc

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Purity: 99.14%

Catalog No. T18617Alias PROTAC Linker 23Cas No. 51644-96-3

NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.14%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR GC

Product Introduction

Bioactivity

Description	NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs.
In vitro	PROTACs consist of two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets the protein of interest. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Synonyms	PROTAC Linker 23

Chemical Properties

Molecular Weight	202.29
Formula	C₁₀H₂₂N₂O₂
Cas No.	51644-96-3
Smiles	C(NCCCCCN)(OC(C)(C)C)=O
Relative Density.	0.972g/mLat 20°C(lit.)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 100 mg/mL (494.34 mM), Sonication is recommended.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	4.9434 mL	24.7170 mL	49.4340 mL	247.1699 mL
5 mM	0.9887 mL	4.9434 mL	9.8868 mL	49.4340 mL
10 mM	0.4943 mL	2.4717 mL	4.9434 mL	24.7170 mL
20 mM	0.2472 mL	1.2358 mL	2.4717 mL	12.3585 mL
50 mM	0.0989 mL	0.4943 mL	0.9887 mL	4.9434 mL
100 mM	0.0494 mL	0.2472 mL	0.4943 mL	2.4717 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc