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NH2-C5-NH-Boc

Name: NH2-C5-NH-Boc
Brand: TargetMol
SKU: T18617
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18617Cas No. 51644-96-3

Alias PROTAC Linker 23

NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs.

NH2-C5-NH-Boc

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Purity: 99.14%

Catalog No. T18617Alias PROTAC Linker 23Cas No. 51644-96-3

NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs.

Pack Size	Price	Availability	Quantity
100 mg	$29	In Stock

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Batch Information

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Purity:99.14%

Resource Download

COA HNMR GC

Product Introduction

Bioactivity

Description	NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs.
In vitro	PROTACs consist of two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets the protein of interest. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Synonyms	PROTAC Linker 23

Chemical Properties

Molecular Weight	202.29
Formula	C₁₀H₂₂N₂O₂
Cas No.	51644-96-3
Smiles	C(NCCCCCN)(OC(C)(C)C)=O
Relative Density.	0.972g/mLat 20°C(lit.)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 100 mg/mL (494.34 mM), Sonication is recommended.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	4.9434 mL	24.7170 mL	49.4340 mL	247.1699 mL
5 mM	0.9887 mL	4.9434 mL	9.8868 mL	49.4340 mL
10 mM	0.4943 mL	2.4717 mL	4.9434 mL	24.7170 mL
20 mM	0.2472 mL	1.2358 mL	2.4717 mL	12.3585 mL
50 mM	0.0989 mL	0.4943 mL	0.9887 mL	4.9434 mL
100 mM	0.0494 mL	0.2472 mL	0.4943 mL	2.4717 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc