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Pirmitegravir
🥰Excellent
Catalog No. T39755Cas No. 2245231-10-9
Alias STP0404
Pirmitegravir (STP0404) is a potent and selective inhibitor of allosteric integrase (ALLINI) targeting the LEDGF/p75 binding site. Pirmitegravir inhibits PBMC. Pirmitegravir inhibits PBMC.Pirmitegravir has significant antiviral activity and may be useful in the study of HIV virus infection.
Pirmitegravir
🥰Excellent
Purity: 99.79%
Catalog No. T39755Alias STP0404Cas No. 2245231-10-9
Pirmitegravir (STP0404) is a potent and selective inhibitor of allosteric integrase (ALLINI) targeting the LEDGF/p75 binding site. Pirmitegravir inhibits PBMC. Pirmitegravir inhibits PBMC.Pirmitegravir has significant antiviral activity and may be useful in the study of HIV virus infection.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $136 | In Stock | |
| 5 mg | $338 | In Stock | |
| 10 mg | $546 | In Stock | |
| 25 mg | $1,090 | In Stock | |
| 50 mg | $1,790 | In Stock | |
| 100 mg | $2,390 | In Stock |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.79%
ee:99.5%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Pirmitegravir (STP0404) is a potent and selective inhibitor of allosteric integrase (ALLINI) targeting the LEDGF/p75 binding site. Pirmitegravir inhibits PBMC. Pirmitegravir inhibits PBMC.Pirmitegravir has significant antiviral activity and may be useful in the study of HIV virus infection. |
| Targets&IC50 | HIV-1:0.41 nM, CEMx174 cells:1.4 nM |
| In vitro | In CEMx174 cells, Pirmitegravir demonstrates an IC50 of 1.4 nM, inhibiting dual tropic HIV-189.6[1]. Pirmitegravir is a highly potent ALLINI, inhibiting both wild-type and Ral-resistant HIV-1 strains, with IC50 values ranging from picomolar to single-digit nanomolar[1].With an IC50 of 0.41 nM against HIV-1NL4-3, Pirmitegravir exhibits no observable cytotoxicity in human PBMCs at 10 μM (TC50 >10μM)[1]. |
| In vivo | For once-daily administration, Pirmitegravir exhibits appropriate PK profiles[1]. The lack of micronucleus-inducing and bone marrow cell proliferation inhibitory potentials in rats (500, 1000, and 2000 mg/kg/day) supports the conclusion that Pirmitegravir is not genotoxic[1].An assessment of the Pharmacokinetics (PK) profile of Pirmitegravir in rat and dog has been conducted[1]. |
| Synonyms | STP0404 |
| Molecular Weight | 495.01 |
| Formula | C27H31ClN4O3 |
| Cas No. | 2245231-10-9 |
| Smiles | [C@@H](OC(C)(C)C)(C(O)=O)C=1C(=C2C(N(CC=3C=NN(C)C3)C(C)=C2C)=NC1C)C4=CC=C(Cl)C=C4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (111.11 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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