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PD-L1-IN-6
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Catalog No. T209571
PD-L1-IN-6 (Compound 16) targets STAT3, with a KD of 90.5 nmol/L, to inhibit the expression of PD-L1 in neutrophils. It enhances the antifungal immune response mediated by neutrophils and is effective when administered orally.
PD-L1-IN-6
PD-L1-IN-6
😃Good
Catalog No. T209571
PD-L1-IN-6 (Compound 16) targets STAT3, with a KD of 90.5 nmol/L, to inhibit the expression of PD-L1 in neutrophils. It enhances the antifungal immune response mediated by neutrophils and is effective when administered orally.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 10 mg | Inquiry | Backorder | Backorder | |
| 50 mg | Inquiry | Backorder | Backorder |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | PD-L1-IN-6 (Compound 16) targets STAT3, with a KD of 90.5 nmol/L, to inhibit the expression of PD-L1 in neutrophils. It enhances the antifungal immune response mediated by neutrophils and is effective when administered orally. |
| In vitro | PD-L1-IN-6 (40 μM) inhibits PD-L1 expression by 80.17% without significant cytotoxicity to neutrophils. It exhibits slight permeability across the blood-brain barrier, with p e measured at 1.22×10^-6 cm/s. |
| In vivo | PD-L1-IN-6 (50-100 mg/kg, oral administration, 3 days) suppresses β-glucan-induced CXCL1 and CXCL2 secretion in a C57BL/6 mouse model infected with C. albicans, promoting neutrophil migration and enhancing neutrophil-mediated antifungal immunity. |
| Formula | C21H24Cl2O6S |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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