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C12-iE-DAP hydrochloride
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Catalog No. TP3723
Alias γ-D-glutamyl-meso-diaminopimelic acid hydrochloride, Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid hydrochloride, C12-iE-DAP hydrochloride
C12-iE-DAP hydrochloride is the hydrochloride salt form of C12-iE-DAP and is a biologically active peptide that functions as an agonist of NOD1, making it a useful research reagent for investigating innate immune recognition, pattern recognition receptor signaling, and host–pathogen interaction pathways.
C12-iE-DAP hydrochloride
Copy Product Info😃Good
Catalog No. TP3723Alias γ-D-glutamyl-meso-diaminopimelic acid hydrochloride, Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid hydrochloride, C12-iE-DAP hydrochloride
C12-iE-DAP hydrochloride is the hydrochloride salt form of C12-iE-DAP and is a biologically active peptide that functions as an agonist of NOD1, making it a useful research reagent for investigating innate immune recognition, pattern recognition receptor signaling, and host–pathogen interaction pathways.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $398 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | C12-iE-DAP hydrochloride is the hydrochloride salt form of C12-iE-DAP and is a biologically active peptide that functions as an agonist of NOD1, making it a useful research reagent for investigating innate immune recognition, pattern recognition receptor signaling, and host–pathogen interaction pathways. |
| Targets&IC50 | NOD1:0.027 nM |
| In vitro | Method: HEK293 cells were engineered using a lentiviral NF-κB–dependent β-galactosidase reporter system to measure NOD1 receptor activation. Result: NOD1 ligand stimulation activated NF-κB signaling in HEK293 cells, enabling quantitative assessment of receptor–ligand interactions via β-galactosidase activity[1]. |
| In vivo | Method: C12-iE-DAP hydrochloride (200 μg/mouse) or TLR4 ligand (5 μg/mouse) was administered intramuscularly in mice, and NF-κB activation was measured across organs. Result: C12-iE-DAP hydrochloride induced maximal NF-κB activation in the liver and small intestine at 5 h post-injection, with minimal activation in kidneys, heart, and small intestine relative to other organs. |
| Synonyms | γ-D-glutamyl-meso-diaminopimelic acid hydrochloride, Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid hydrochloride, C12-iE-DAP hydrochloride |
| Molecular Weight | 501.61 (free base) |
| Formula | C24H43N3O8.xHCl |
| Smiles | CCCCCCCCCCCC(N[C@@H](C(O)=O)CCC(NC(CCCC(N)C(O)=O)C(O)=O)=O)=O.Cl |
| Sequence | Lauroyl-γ-d-Glu-meso-diaminopimelic acid |
| Sequence Short | E |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: 80.00 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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