CD161 Protein, Human, Recombinant (N-hFc)

Name: CD161 Protein, Human, Recombinant (N-hFc)
Brand: TargetMol
SKU: TMPJ-01095
Rating: 4.5 (1 reviews)

(Synonyms: NKR-P1A, NKRP1A, Natural killer cell surface protein P1A, KLRB1, Killer cell lectin-like receptor subfamily B member 1, HNKR-P1a, C-type lectin domain family 5 member B, CLEC5B, CD161) Copy Product Info

Synonyms: NKR-P1A, NKRP1A, Natural killer cell surface protein P1A, KLRB1, Killer cell lectin-like receptor subfamily B member 1, HNKR-P1a, C-type lectin domain family 5 member B, CLEC5B, CD161

Catalog No. TMPJ-01095 Copy Product Info

CD161 Protein, Human, Recombinant (N-hFc) is expressed in HEK293 mammalian cells with N-Fc tag. The predicted molecular weight is 55-70 KDa and the accession number is Q12918.

Pack Size	Price	USA Stock	Global Stock
5 µg	$55	7-10 days	7-10 days
10 µg	$86	7-10 days	7-10 days
20 µg	$137	7-10 days	7-10 days
50 µg	$262	7-10 days	7-10 days
100 µg	$489	7-10 days	7-10 days
200 µg	$929	7-10 days	7-10 days
500 µg	$2,170	7-10 days	7-10 days
1 mg	$3,250	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	CD161 Protein, Human, Recombinant (N-hFc) is expressed in HEK293 mammalian cells with N-Fc tag. The predicted molecular weight is 55-70 KDa and the accession number is Q12918.
Species	Human
Expression System	HEK293 Cells
Tag	N-hFc
Accession Number	Q12918
Amino Acid	Lys68-Ser225
Construction	Lys68-Ser225
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	NKR-P1A, NKRP1A, Natural killer cell surface protein P1A, KLRB1, Killer cell lectin-like receptor subfamily B member 1, HNKR-P1a, C-type lectin domain family 5 member B, CLEC5B, CD161
Research Background	Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

Chemical Properties

Molecular Weight

55-70 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.