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Darizmetinib

Name: Darizmetinib
Brand: TargetMol
SKU: T72956
Price: 66 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72956Cas No. 2369583-33-3

Alias HRX215, HRX-0215

Darizmetinib (HRX215, HRX-0215) is an MKK4 inhibitor. Inhibition of MKK4 leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration.

Darizmetinib

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Purity: 99.57%

Catalog No. T72956Alias HRX215, HRX-0215Cas No. 2369583-33-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$66	In Stock	In Stock
2 mg	$96	In Stock	In Stock
5 mg	$158	In Stock	In Stock
10 mg	$248	In Stock	In Stock
25 mg	$360	In Stock	In Stock
50 mg	$445	In Stock	In Stock
100 mg	$652	-	In Stock
1 mL x 10 mM (in DMSO)	$159	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:White to Yellow

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Darizmetinib (HRX215, HRX-0215) is an MKK4 inhibitor. Inhibition of MKK4 leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration.
Targets&IC50	MAP2K4:< 500 nM, MKK4:0.02 µM
Synonyms	HRX215, HRX-0215

Chemical Properties

Molecular Weight	457.45
Formula	C₂₁H₁₇F₂N₅O₃S
Cas No.	2369583-33-3
Smiles	O=C(C1=NNC2=NC=C(C=C21)C=3C=CN=CC3)C4=CC=C(F)C(NS(=O)(=O)CCC)=C4F

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 180 mg/mL (393.49 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1860 mL	10.9302 mL	21.8603 mL	109.3016 mL
5 mM	0.4372 mL	2.1860 mL	4.3721 mL	21.8603 mL
10 mM	0.2186 mL	1.0930 mL	2.1860 mL	10.9302 mL
20 mM	0.1093 mL	0.5465 mL	1.0930 mL	5.4651 mL
50 mM	0.0437 mL	0.2186 mL	0.4372 mL	2.1860 mL
100 mM	0.0219 mL	0.1093 mL	0.2186 mL	1.0930 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc