Thalidomide-PEG2-C2-NH2

Name: Thalidomide-PEG2-C2-NH2
Brand: TargetMol
SKU: T18813
Rating: 4.5 (1 reviews)

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Catalog No. T18813Cas No. 2093416-32-9

Alias Thalidomide-NH-PEG2-C2-NH2

Thalidomide-O-amido-PEG3-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

Thalidomide-PEG2-C2-NH2

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Catalog No. T18813Alias Thalidomide-NH-PEG2-C2-NH2Cas No. 2093416-32-9

Thalidomide-O-amido-PEG3-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

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Product Introduction

Bioactivity

Description	Thalidomide-O-amido-PEG3-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].
In vitro	PROTACs consist of two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase and the other targets the [target protein]. These compounds leverage the intracellular ubiquitin-proteasome system to selectively degrade [target proteins].
Synonyms	Thalidomide-NH-PEG2-C2-NH2

Chemical Properties

Molecular Weight	404.42
Formula	C₁₉H₂₄N₄O₆
Cas No.	2093416-32-9
Smiles	O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCOCCOCCN)C3C2=O)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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