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Anti-CD200 Antibody-APC (2H839)
🥰Excellent
Catalog No. TMAY-03079A
Anti-CD200 Antibody-APC (2H839) is a APC-conjugated Rabbit antibody targeting CD200. Anti-CD200 Antibody-APC (2H839) can be used in FCM.
Anti-CD200 Antibody-APC (2H839)
Anti-CD200 Antibody-APC (2H839)
🥰Excellent
Catalog No. TMAY-03079A
Anti-CD200 Antibody-APC (2H839) is a APC-conjugated Rabbit antibody targeting CD200. Anti-CD200 Antibody-APC (2H839) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD200 Antibody-APC (2H839) is a APC-conjugated Rabbit antibody targeting CD200. Anti-CD200 Antibody-APC (2H839) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 2H839 |
| Reactivity | Mouse |
| Verified Activity | Analysis of CD200 expression on spleen lymphocytes. |
| Application | FCM |
| Recommended Dose | 2 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD200 (rM CD200; TMPY-01160; O54901.1; Met1-Gly232) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in some human malignancies. Besides, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | APC |
| Others Formats | Unconjugated/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Mouse CD200 protein (TMPY-01160) |
| Antigen Species | Mouse |
| Biology Area | Neuroinflammation, Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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