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PTP1B-IN-33
Catalog No. T212839 Copy Product Info
Purity: 99.93%
🥰Excellent
PTP1B-IN-33 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 2.45 μM against human PTP1B, showing more than 20-fold selectivity over SHP2. It enhances π-alkyl interactions with PTP1B, thereby promoting closure of the WPD loop. PTP1B-IN-33 can be used in studies on cancer, diabetes, and autoimmune deficiency diseases.
PTP1B-IN-33
Copy Product Info🥰Excellent
Catalog No. T212839
PTP1B-IN-33 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 2.45 μM against human PTP1B, showing more than 20-fold selectivity over SHP2. It enhances π-alkyl interactions with PTP1B, thereby promoting closure of the WPD loop. PTP1B-IN-33 can be used in studies on cancer, diabetes, and autoimmune deficiency diseases.
Cas No. 77500-30-2
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | - | In Stock | |
| 10 mg | $691 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,960 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.93%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | PTP1B-IN-33 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 2.45 μM against human PTP1B, showing more than 20-fold selectivity over SHP2. It enhances π-alkyl interactions with PTP1B, thereby promoting closure of the WPD loop. PTP1B-IN-33 can be used in studies on cancer, diabetes, and autoimmune deficiency diseases. |
| Targets&IC50 | PTP1B (human):2.45 μM |
| In vitro | Methods: Human PTP1B and SHP2 PTP proteins were treated with PTP1B-IN-33, and their structural changes and interactions were detected. Results: PTP1B-IN-33 induced a significantly higher degree of WPD loop closure in human PTP1B (5.4 Å) than in human SHP2 PTP (1.2 Å), and enhanced the stability of PTP1B via strong interaction with R47, a residue of the phosphotyrosine (pTyr) loop [1]. |
| Molecular Weight | 306.32 |
| Formula | C18H14N2O3 |
| Cas No. | 77500-30-2 |
| Smiles | O=C(NC=1C=CC=CC1)C=2OC(=CC2)C(=O)NC=3C=CC=CC3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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