EGFR Protein, Human, Recombinant (aa 668-1210, His)

Catalog No. TMPC-00244 Copy Product Info

EGFR Protein, Human, Recombinant (aa 668-1210, His) is expressed in Baculovirus-Insect Cells. The accession number is P00533.

EGFR Protein, Human, Recombinant (aa 668-1210, His)

Catalog No. TMPC-00244

Copy Product Info

EGFR Protein, Human, Recombinant (aa 668-1210, His) is expressed in Baculovirus-Insect Cells. The accession number is P00533.

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10 μg	$1,390	Inquiry	Inquiry

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	The specific activity of EGFR was determined to be 31-36 nmol /min/mg by ADP-Glo kinase assay.
Description	EGFR Protein, Human, Recombinant (aa 668-1210, His) is expressed in Baculovirus-Insect Cells. The accession number is P00533.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-His
Accession Number	P00533
Synonyms	Receptor tyrosine-protein kinase erbB-1,Proto-oncogene c-ErbB-1,HER1,ERBB1,ERBB,Epidermal growth factor receptor,EGFR
Construction	Recombinant human EGFR (668-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Protein Purity	>80% as determined by SDS-PAGE.
Molecular Weight	68-78 kDa
Formulation	Supplied as sterile 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.25 mM DTT, 25% glycerol.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy