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EGFR Protein, Human, Recombinant (aa 668-1210, His)
(Synonyms: Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1, HER1, ERBB1, ERBB, Epidermal growth factor receptor, EGFR) Copy Product InfoSynonyms: Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1, HER1, ERBB1, ERBB, Epidermal growth factor receptor, EGFR
Catalog No. TMPC-00244 Copy Product Info
EGFR Protein, Human, Recombinant (aa 668-1210, His) is expressed in Baculovirus-Insect Cells. The accession number is P00533.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 μg | $1,390 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | The specific activity of EGFR was determined to be 31-36 nmol /min/mg by ADP-Glo kinase assay. |
| Description | EGFR Protein, Human, Recombinant (aa 668-1210, His) is expressed in Baculovirus-Insect Cells. The accession number is P00533. |
| Species | Human |
| Expression System | Baculovirus-Insect Cells |
| Tag | N-His |
| Accession Number | P00533 |
| Construction | Recombinant human EGFR (668-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. |
| Protein Purity | >80% as determined by SDS-PAGE.  |
| Formulation | Supplied as sterile 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.25 mM DTT, 25% glycerol. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products. |
| Synonyms | Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1, HER1, ERBB1, ERBB, Epidermal growth factor receptor, EGFR |
| Research Background | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 68-78 kDa |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: EGFR Protein, Human, Recombinant (aa 668-1210, His) chemical structure | EGFR Protein, Human, Recombinant (aa 668-1210, His) molecular weight
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