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Genz-123346 free base

Name: Genz-123346 free base
Brand: TargetMol
SKU: T4049
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4049Cas No. 491833-30-8

Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.

Genz-123346 free base

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Purity: 99.41%

Catalog No. T4049Cas No. 491833-30-8

Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$68	In Stock
25 mg	$126	In Stock
50 mg	$197	In Stock
100 mg	$292	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Batch Information

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Purity:99.41%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.
Targets&IC50	GM1:14 nM.
In vivo	GLPG-1690 was able to cause a sustained reduction of LPA levels in plasma in vivo and was shown to be efficacious in a bleomycin-induced pulmonary fibrosis model in mice and in reducing extracellular matrix deposition in the lung while also reducing LPA 18:2 content in bronchoalveolar lavage fluid.

Chemical Properties

Molecular Weight	418.57
Formula	C₂₄H₃₈N₂O₄
Cas No.	491833-30-8
Smiles	CCCCCCCCC(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc2OCCOc2c1
Relative Density.	1.111 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (119.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3891 mL	11.9454 mL	23.8909 mL	119.4543 mL
5 mM	0.4778 mL	2.3891 mL	4.7782 mL	23.8909 mL
10 mM	0.2389 mL	1.1945 mL	2.3891 mL	11.9454 mL
20 mM	0.1195 mL	0.5973 mL	1.1945 mL	5.9727 mL
50 mM	0.0478 mL	0.2389 mL	0.4778 mL	2.3891 mL
100 mM	0.0239 mL	0.1195 mL	0.2389 mL	1.1945 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc