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Inolitazone dihydrochloride

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Catalog No. T15580Cas No. 223132-38-5
Alias RS5444 dihydrochloride, Efatutazone dihydrochloride, CS-7017 dihydrochloride

Inolitazone dihydrochloride is an effective, high-affinity PPARγ agonist; its biological activity is dependent on PPARγ (IC50:0.8 nM) to inhibit cell growth. Inolitazone dihydrochloride enhances the role of cell cycle kinase inhibitor p21 WAF1/CIP1.

Inolitazone dihydrochloride
Other Forms of Inolitazone dihydrochloride:

Inolitazone dihydrochloride

😃Good
Catalog No. T15580Alias RS5444 dihydrochloride, Efatutazone dihydrochloride, CS-7017 dihydrochlorideCas No. 223132-38-5
Inolitazone dihydrochloride is an effective, high-affinity PPARγ agonist; its biological activity is dependent on PPARγ (IC50:0.8 nM) to inhibit cell growth. Inolitazone dihydrochloride enhances the role of cell cycle kinase inhibitor p21 WAF1/CIP1.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,0701-2 weeks1-2 weeks
50 mg$1,3901-2 weeks1-2 weeks
100 mg$2,2201-2 weeks1-2 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Product Introduction

Bioactivity
Description
Inolitazone dihydrochloride is an effective, high-affinity PPARγ agonist; its biological activity is dependent on PPARγ (IC50:0.8 nM) to inhibit cell growth. Inolitazone dihydrochloride enhances the role of cell cycle kinase inhibitor p21 WAF1/CIP1.
SynonymsRS5444 dihydrochloride, Efatutazone dihydrochloride, CS-7017 dihydrochloride
Chemical Properties
Molecular Weight575.51
FormulaC27H28Cl2N4O4S
Cas No.223132-38-5
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25 mg/mL (43.44 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.48 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7376 mL8.6879 mL17.3759 mL86.8795 mL
5 mM0.3475 mL1.7376 mL3.4752 mL17.3759 mL
10 mM0.1738 mL0.8688 mL1.7376 mL8.6879 mL
20 mM0.0869 mL0.4344 mL0.8688 mL4.3440 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RS-5444 DihydrochlorideRS5444 DihydrochlorideRS-5444RS5444RS 5444 DihydrochlorideRS 5444PPARγInolitazone DihydrochlorideInolitazone dihydrochlorideInolitazoneEfatutazone DihydrochlorideEfatutazoneCS-7017 DihydrochlorideCS7017 DihydrochlorideCS-7017CS7017CS 7017 DihydrochlorideCS 7017
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