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Thiophene-2

Name: Thiophene-2
Brand: TargetMol
SKU: T40520
Rating: 4.5 (1 reviews)

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Catalog No. T40520Cas No. 420089-51-6

Alias TP2, Thiophene-2

Thiophene-2 (TP2) is a targeted inhibitor of polyketide synthase 13 (Pks13), specifically designed to disrupt mycolic acid biosynthesis, effectively inducing rapid cell death in mycobacteria. It demonstrates notable anti-tuberculosis activity and exhibits a minimum inhibitory concentration (MIC) value of 1 μM against Mycobacterium tuberculosis.

Thiophene-2

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Catalog No. T40520Alias TP2, Thiophene-2Cas No. 420089-51-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$970	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Thiophene-2 (TP2) is a targeted inhibitor of polyketide synthase 13 (Pks13), specifically designed to disrupt mycolic acid biosynthesis, effectively inducing rapid cell death in mycobacteria. It demonstrates notable anti-tuberculosis activity and exhibits a minimum inhibitory concentration (MIC) value of 1 μM against Mycobacterium tuberculosis.
Targets&IC50	Mycobacterium tuberculosis:1 μM (MIC)
In vitro	In vitro, TP inhibits the fatty acyl-AMP's ability to bind with Pks13, and Thiophene-2 (TP2; 0-125 μM) demonstrates a dose-dependent inhibition of this activity in both wild-type Mycobacterium tuberculosis (Mtb) Pks13 (Pks13_WT) and the TP-resistant F79S mutant protein, specifically affecting palmitic acid (FL C16) loading. Furthermore, Thiophene-2 exhibits significant cytotoxic activity, with an IC50 of 17.5 μM against monkey kidney Vero cells and 7.30 μM against human liver carcinoma HepG2 cells. Notably, it also shows considerable intracellular killing capacity within BCG-infected J774A.1 macrophage cells at concentrations of 12.8 μM[1].
Synonyms	TP2, Thiophene-2

Chemical Properties

Molecular Weight	419.37
Formula	C₁₈H₁₄F₅NO₃S
Cas No.	420089-51-6
Smiles	O=C(OC)C1=C(SC2=C1CCCCC2)NC(=O)C=3C(F)=C(F)C(F)=C(F)C3F

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc