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Anti-FMR1 Antibody (9X925)
😃Good
Catalog No. TMAC-01524
Alias zgc:66226, wu:fd18c10, wu:fb16f11, Protein FMR-1, Protein FMR1, POF1, POF, MGC87458, fxr1, FRAXA, fragile X mental retardation, autosomal homolog 1, fragile X mental retardation syndrome-related protein 1, Fragile X mental retardation protein 1, Fragile X mental retardation protein, Fragile X mental retardation 1 protein, Fragile X mental retardation 1, FMRP, FMR1_HUMAN, Fmr1 gene, Fmr1, FMR 1
Anti-FMR1 Antibody (9X925) is a Rabbit antibody targeting FMR1. Anti-FMR1 Antibody (9X925) can be used in WB,ICC/IF,IHC.
Anti-FMR1 Antibody (9X925)
Anti-FMR1 Antibody (9X925)
😃Good
Catalog No. TMAC-01524Alias zgc:66226, wu:fd18c10, wu:fb16f11, Protein FMR-1, Protein FMR1, POF1, POF, MGC87458, fxr1, FRAXA, fragile X mental retardation, autosomal homolog 1, fragile X mental retardation syndrome-related protein 1, Fragile X mental retardation protein 1, Fragile X mental retardation protein, Fragile X mental retardation 1 protein, Fragile X mental retardation 1, FMRP, FMR1_HUMAN, Fmr1 gene, Fmr1, FMR 1
Anti-FMR1 Antibody (9X925) is a Rabbit antibody targeting FMR1. Anti-FMR1 Antibody (9X925) can be used in WB,ICC/IF,IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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| Description | Anti-FMR1 Antibody (9X925) is a Rabbit antibody targeting FMR1. Anti-FMR1 Antibody (9X925) can be used in WB,ICC/IF,IHC. |
| Synonyms | zgc:66226, wu:fd18c10, wu:fb16f11, Protein FMR-1, Protein FMR1, POF1, POF, MGC87458, fxr1, FRAXA, fragile X mental retardation, autosomal homolog 1, fragile X mental retardation syndrome-related protein 1, Fragile X mental retardation protein 1, Fragile X mental retardation protein, Fragile X mental retardation 1 protein, Fragile X mental retardation 1, FMRP, FMR1_HUMAN, Fmr1 gene, Fmr1, FMR 1 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of FMRP on different cells lysates using anti-FMRP antibody at 1/500 dilution. Positive control: Lane 1: Hela, Lane 2: K562. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-FMRP antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-FMRP antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-FMRP antibody. Counter stained with hematoxylin. 5. ICC staining FMRP in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining FMRP in HepG2 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. ICC staining FMRP in SH-SY5Y cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| Application | |
| Recommended Dose | WB: 1:5000-10000; IHC: 1:50-200; ICC/IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Fragile X syndrome is the most frequent form of inherited mental retardation and is the result of transcriptional silencing of the FMR1 gene on the X chromosome. The FMR1 gene contains a distinct CpG dinucleotide repeat located in the 5' untranslated region of the gene. In fragile X syndrome this tandem repeat is substantially amplified and subjected to extensive methylation and enhanced transcriptional silencing. The FMR1 protein (or FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle. It contains several features that are characteristics of RNA-binding proteins, including two hnRNPK homology (KH) domains and an RGG amino acid motif (RGG box). FMR1 localizes to both the nucleus and the cytoplasm and can also interact with two fragile X syndrome related factors, FXR1 and FXR2, which form heterodimers through their N-terminal coiled-coil domains. Since FMR1 contains both a nuclear localization signal and a nuclear export signal it is also implicated in the nucleocytoplasmic transport of mRNAs. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 71 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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