TSHR Protein, Human, Recombinant (His)

Name: TSHR Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-04853
Rating: 4.5 (1 reviews)

(Synonyms: TSHR, TSH Receptor, LGR3, hTSHR-I, CHNG1) Copy Product Info

Synonyms: TSHR, TSH Receptor, LGR3, hTSHR-I, CHNG1

Catalog No. TMPY-04853 Copy Product Info

Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed predominantly nuclei/peri-nuclei localization of TSHR in cancerous tissues but cell membrane localization in non-cancerous parts. Overexpression of TSHR was found in a great majority of HCC tissues and associated with unfavorable prognosis.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$47	7-10 days	7-10 days
10 µg	$74	7-10 days	7-10 days
20 µg	$118	7-10 days	7-10 days
50 µg	$228	7-10 days	7-10 days
100 µg	$392	7-10 days	7-10 days
200 µg	$670	7-10 days	7-10 days
500 µg	$1,350	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:90.1%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Label Recombinant Human TSH alpha & beta Heterodimer Protein (His Tag) with biotin. Immobilized Recombinant Human TSH Receptor/TSHR (His Tag) (Cat#TMPY-04853) at 2 μg/ml (100 μl/well) can bind biotinylated Recombinant Human TSH alpha & beta Heterodimer Protein, the EC50 is 150-450 ng/mL.
Description	Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed predominantly nuclei/peri-nuclei localization of TSHR in cancerous tissues but cell membrane localization in non-cancerous parts. Overexpression of TSHR was found in a great majority of HCC tissues and associated with unfavorable prognosis.
Species	Human
Expression System	Baculovirus Insect Cells
Tag	C-His
Accession Number	P16473
Construction	A DNA sequence encoding the human TSHR (NP_000360.2) (Gly21-Gly413) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Gly
Protein Purity	> 85 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 150 mM NaCl, 10% Glycerol, 1 mM TCEP, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	TSHR, TSH Receptor, LGR3, hTSHR-I, CHNG1
Research Background	Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed predominantly nuclei/peri-nuclei localization of TSHR in cancerous tissues but cell membrane localization in non-cancerous parts. Overexpression of TSHR was found in a great majority of HCC tissues and associated with unfavorable prognosis.

Chemical Properties

Molecular Weight

46.1 kDa (predicted); 56.6 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.