Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed predominantly nuclei/peri-nuclei localization of TSHR in cancerous tissues but cell membrane localization in non-cancerous parts. Overexpression of TSHR was found in a great majority of HCC tissues and associated with unfavorable prognosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 μg | In stock | $ 228.00 | |
100 μg | 5 days | $ 392.00 | |
200 μg | 5 days | $ 670.00 | |
500 μg | 5 days | $ 1,350.00 |
Biological Information | Testing in progress |
Description | Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed predominantly nuclei/peri-nuclei localization of TSHR in cancerous tissues but cell membrane localization in non-cancerous parts. Overexpression of TSHR was found in a great majority of HCC tissues and associated with unfavorable prognosis. |
Species | Human |
Expression System | Baculovirus-Insect Cells |
Tag | His |
Accession Number | A0A0A0MTJ0 |
Synonyms | TSHR, hTSHR-I, TSH Receptor, LGR3, CHNG1 |
Construction | A DNA sequence encoding the human TSHR (NP_000360.2) (Gly21-Gly413) was expressed with a polyhistidine tag at the C-terminus. |
Protein Purity |
> 85 % as determined by SDS-PAGE.
|
Molecular Weight | 46.1 kDa (predicted) |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from sterile 50mM Tris, 150mM NaCl, 10% Glycerol, 1mM TCEP, pH 7.5. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
Reconstitution | A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information. |
Stability & Storage |
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed predominantly nuclei/peri-nuclei localization of TSHR in cancerous tissues but cell membrane localization in non-cancerous parts. Overexpression of TSHR was found in a great majority of HCC tissues and associated with unfavorable prognosis. |
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TSHR Protein, Human, Recombinant (His) TSHR LGR 3 hTSHR-I LGR-3 TSH Receptor LGR3 CHNG1 CHNG-1 CHNG 1 recombinant recombinant-proteins proteins protein