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L-Allylglycine

Catalog No. T37190   CAS 16338-48-0

L-Allylglycine is a potent inhibitor of the synthetic enzyme for GABA, glutamic acid decarboxylase.

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L-Allylglycine Chemical Structure
L-Allylglycine, CAS 16338-48-0
Pack Size Availability Price/USD Quantity
500 mg In stock $ 87.00
1 g In stock $ 148.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description L-Allylglycine is a potent inhibitor of the synthetic enzyme for GABA, glutamic acid decarboxylase.
In vitro L-allylglycine inhibits glutamic acid decarboxylase(GAD) only when used at high concentrations (1-80 mM). The more potent in vivo activity can be attributed to metabolic conversion of L-allylglycine to 2-keto-4-pentanoic acid, a more potent convulsant and GAD inhibitor[1].
In vivo The stereoisomers of allylglycine were injected into the posterior hypothalamus at a site also shown to be reactive to bicuculline. Injection of L-allylglycine but not D-allylglycine caused substantial increases in heart rate but only slight increases in blood pressure[1].
Molecular Weight 115.13
Formula C5H9NO2
CAS No. 16338-48-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

PBS (pH 7.2): 10 mg/mL

Ethanol: Insoluble

TargetMolReferences and Literature

1. Abshire VM, et al. Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate. Neuropharmacology. 1988 Nov;27(11):1171-7. 2. Meldrum BS, et al. Redistribution of transmitter amino acids in rat hippocampus and cerebellum during seizures induced by L-allylglycine and bicuculline: an immunocytochemical study with antisera against conjugated GABA, glutamate and aspartate. Neuroscience. 1987 Jul;22(1):17-27.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Neuronal Signaling Compound Library Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Metabolism Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max

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Keywords

L-Allylglycine 16338-48-0 Membrane transporter/Ion channel Metabolism Neuroscience Dehydrogenase GABA Receptor Inhibitor LAllylglycine L Allylglycine inhibit inhibitor

 

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