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L-Allylglycine

Name: L-Allylglycine
Brand: TargetMol
SKU: T37190
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37190Cas No. 16338-48-0

L-Allylglycine is a potent inhibitor of the synthetic enzyme for GABA, glutamic acid decarboxylase.

L-Allylglycine

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Catalog No. T37190Cas No. 16338-48-0

L-Allylglycine is a potent inhibitor of the synthetic enzyme for GABA, glutamic acid decarboxylase.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	-

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:≥98%

Appearance:Solid

Color:White

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	L-Allylglycine is a potent inhibitor of the synthetic enzyme for GABA, glutamic acid decarboxylase.
In vitro	L-allylglycine inhibits glutamic acid decarboxylase(GAD) only when used at high concentrations (1-80 mM). The more potent in vivo activity can be attributed to metabolic conversion of L-allylglycine to 2-keto-4-pentanoic acid, a more potent convulsant and GAD inhibitor[1].
In vivo	The stereoisomers of allylglycine were injected into the posterior hypothalamus at a site also shown to be reactive to bicuculline. Injection of L-allylglycine but not D-allylglycine caused substantial increases in heart rate but only slight increases in blood pressure[1].

Chemical Properties

Molecular Weight	115.13
Formula	C₅H₉NO₂
Cas No.	16338-48-0
Smiles	N[C@@H](CC=C)C(O)=O
Relative Density.	1.1808 g/cm3 (Estimated)
Sequence	H-Gly(allyl)-OH
Sequence Short	X

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

PBS (pH 7.2): 10 mg/mL (86.86 mM), Sonication is recommended.

Ethanol: Insoluble

Solution Preparation Table

PBS (pH 7.2)

	1mg	5mg	10mg	50mg
1 mM	8.6858 mL	43.4292 mL	86.8583 mL	434.2917 mL
5 mM	1.7372 mL	8.6858 mL	17.3717 mL	86.8583 mL
10 mM	0.8686 mL	4.3429 mL	8.6858 mL	43.4292 mL
20 mM	0.4343 mL	2.1715 mL	4.3429 mL	21.7146 mL
50 mM	0.1737 mL	0.8686 mL	1.7372 mL	8.6858 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc