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AR20.5
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Catalog No. T9901A-991 Copy Product Info
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AR20.5 represents a highly specialized murine monoclonal antibody specifically engineered to target the tumor-associated antigen MUC1 with exceptional binding affinity. It effectively facilitates the measurable induction of antigen-specific T-cell immune responses across various preclinical experimental models to evaluate the synergy between antibody-mediated vaccination and immune checkpoint blockade during strictly monitored laboratory observation periods and functional tumor challenge assays.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Antibody Information
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| Description | AR20.5 represents a highly specialized murine monoclonal antibody specifically engineered to target the tumor-associated antigen MUC1 with exceptional binding affinity. It effectively facilitates the measurable induction of antigen-specific T-cell immune responses across various preclinical experimental models to evaluate the synergy between antibody-mediated vaccination and immune checkpoint blockade during strictly monitored laboratory observation periods and functional tumor challenge assays. |
| In vitro | In MUC1-expressing pancreatic cancer cells, AR20.5 enhanced T cell-mediated cytotoxicity and increased IFN-gamma production when combined with PD-L1 blockade [1]. |
| In vivo | In MUC1.Tg mice challenged with pancreatic tumors, the combination of AR20.5 and anti-PD-L1 significantly inhibited tumor progression and prolonged survival [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | MUC1 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: AR20.5 chemical structure | AR20.5 in vivo | AR20.5 in vitro
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