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Pirenzepine dihydrochloride
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Catalog No. T1542Cas No. 29868-97-1
Alias Tabe, Pirenzepine HCl, LS519, Bisvanil
Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist, inhibiting gastric secretion.
Pirenzepine dihydrochloride
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Purity: 99.62%
Catalog No. T1542Alias Tabe, Pirenzepine HCl, LS519, BisvanilCas No. 29868-97-1
Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist, inhibiting gastric secretion.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $33 | In Stock | In Stock | |
| 500 mg | $65 | In Stock | In Stock | |
| 1 g | $93 | - | In Stock | |
| 1 mL x 10 mM (in H2O) | $36 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.62%
Appearance:Solid
Color:White
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Product Introduction
Pirenzepine dihydrochloride AI Summary
Pirenzepine dihydrochloride exhibits a range of bioactivities, including the inhibition of various enzymes and viral activities. It inhibits Lamin A splicing (22387.2 nM), Plasmodium falciparum proliferation (14125.4 nM), Human Apurinic/apyrimidinic Endonuclease 1 (APE1, 28183.8 nM), Histone Lysine Methyltransferase G9a (56234.1 nM), Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1, 1122.0 nM), and Polymerase Eta (177.8 nM). Additionally, it inhibits the entry or binding of the Marburg Virus (398.1 nM) and induces DNA re-replication in MCF 10A normal breast cells.
In OATP1B3-transfected and OATP1B1-transfected CHO cells, Pirenzepine dihydrochloride shows high inhibitory activity in sodium fluorescein uptake assays with inhibition percentages of 100.6% and 103.82%, respectively, at an equimolar substrate-inhibitor concentration of 10 µM.
Against SARS-CoV-2, Pirenzepine dihydrochloride has shown low inhibitory activity on cell viability in Vero E6 cells with an inhibition index of 0.1161 at an MOI of 0.002 after 72 hours. However, it demonstrates some antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells (-3.82% inhibition at 10 µM after 48 hours) and the 3CL-Pro protease activity (23.31% inhibition at 20 µM). Moreover, it shows slight antiviral activity in reducing cytotoxicity in VERO-6 cells (-0.08% at 10 µM concentration after 48 hours exposure to the virus)..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist, inhibiting gastric secretion. |
| Synonyms | Tabe, Pirenzepine HCl, LS519, Bisvanil |
| Molecular Weight | 424.32 |
| Formula | C19H21N5O2·2HCl |
| Cas No. | 29868-97-1 |
| Smiles | Cl.Cl.CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 10 mM, Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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