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PPAR agonist 4
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Catalog No. T209507
PPAR agonist4 (Compound 12) is an orally active PPAR agonist that activates PPARα, PPARδ, and PPARγ with EC50 values of 0.7 μM, 0.7 μM, and 1.8 μM, respectively. It also exhibits anti-hepatic fibrosis activity.
PPAR agonist 4
PPAR agonist 4
😃Good
Catalog No. T209507
PPAR agonist4 (Compound 12) is an orally active PPAR agonist that activates PPARα, PPARδ, and PPARγ with EC50 values of 0.7 μM, 0.7 μM, and 1.8 μM, respectively. It also exhibits anti-hepatic fibrosis activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | PPAR agonist4 (Compound 12) is an orally active PPAR agonist that activates PPARα, PPARδ, and PPARγ with EC50 values of 0.7 μM, 0.7 μM, and 1.8 μM, respectively. It also exhibits anti-hepatic fibrosis activity. |
| Targets&IC50 | PPARγ:1.8 μM (EC50), PPARα:0.7 μM (EC50), PPARδ:0.7 μM (EC50) |
| In vitro | PPAR agonist 4 (3-10 μM) dose-dependently enhances the expression of PPARα/δ target genes CPT1A, PDK4, and ANGPTL4 in HepG2 cells, as well as PPARγ target genes CD36 and FABP4 in HEK293 cells. |
| In vivo | PPAR agonist 4 (3-30 mg/kg, oral, 3 weeks) effectively reduces collagen deposition and inhibits inflammatory cell infiltration in a mouse model of liver fibrosis induced by CCl4. |
| Formula | C23H28F3N3O3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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