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kynureninase/KYNU Protein, Mouse, Recombinant (His)
(Synonyms: kynureninase, 4432411A05Rik) Copy Product InfoSynonyms: kynureninase, 4432411A05Rik
Catalog No. TMPY-02418 Copy Product Info
kynureninase/KYNU Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 53.7 kDa and the accession number is Q9CXF0.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $129 | 7-10 days | 7-10 days | |
| 20 µg | $208 | 7-10 days | 7-10 days | |
| 50 µg | $419 | 7-10 days | 7-10 days | |
| 100 µg | $812 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Measured by its ability to oxidize 3-hydroxykynurenine. The specific activity is > 100 pmoles/min/μg. |
| Description | kynureninase/KYNU Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 53.7 kDa and the accession number is Q9CXF0. |
| Species | Mouse |
| Expression System | Baculovirus Insect Cells |
| Tag | C-His |
| Accession Number | Q9CXF0 |
| Construction | A DNA sequence encoding the mouse KYNU (Q9CXF0) (Met 1-Ser 464) was expressed，with a C-terminal polyhistidine tag. Predicted N terminal: Met |
| Protein Purity | > 94 % as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Supplied as sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.0. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | kynureninase, 4432411A05Rik |
| Research Background | KYNU (Kynureninase) is a Protein Coding gene. KYNU is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Genetic studies in the mouse and the human suggest that kynureninase activity may influence blood pressure and renal function. The gene coding kynureninase (KYNU) is also located on chromosome band 2q14-q23, where a linkage peak for essential hypertension was previously detected in the Chinese Han population. The results show that the rare KYNU variant Arg188Gln affects kynureninase activity and are consistent with the hypothesis that this mutation can predispose to essential hypertension. Diseases associated with KYNU include Hydroxykynureninuria and Vertebral, Cardiac, Renal, And Limb Defects Syndrome 2. |
| Molecular Weight | 53.7 kDa (predicted); 47 kDa (reducing conditions) |
| Shipping | Proteins are shipped with blue ice. |
| Storage | It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: kynureninase/KYNU Protein, Mouse, Recombinant (His) chemical structure | kynureninase/KYNU Protein, Mouse, Recombinant (His) molecular weight
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