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Anti-GCN2 Antibody (7U574)
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Catalog No. TMAC-01637
Alias MGCN2, KIAA1338, GCN2-like protein, GCN2 eIF2alpha kinase, GCN2, Eukaryotic Translation Initiation Factor 2-alpha kinase 4, Eukaryotic Translation Initiation Factor 2 alpha kinase 4, Eif2ak4, EIF2AK4, E2AK4
Anti-GCN2 Antibody (7U574) is a Rabbit antibody targeting GCN2. Anti-GCN2 Antibody (7U574) can be used in WB,ICC,IHC,FCM.
Anti-GCN2 Antibody (7U574)
Anti-GCN2 Antibody (7U574)
😃Good
Catalog No. TMAC-01637Alias MGCN2, KIAA1338, GCN2-like protein, GCN2 eIF2alpha kinase, GCN2, Eukaryotic Translation Initiation Factor 2-alpha kinase 4, Eukaryotic Translation Initiation Factor 2 alpha kinase 4, Eif2ak4, EIF2AK4, E2AK4
Anti-GCN2 Antibody (7U574) is a Rabbit antibody targeting GCN2. Anti-GCN2 Antibody (7U574) can be used in WB,ICC,IHC,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-GCN2 Antibody (7U574) is a Rabbit antibody targeting GCN2. Anti-GCN2 Antibody (7U574) can be used in WB,ICC,IHC,FCM. |
| Synonyms | MGCN2, KIAA1338, GCN2-like protein, GCN2 eIF2alpha kinase, GCN2, Eukaryotic Translation Initiation Factor 2-alpha kinase 4, Eukaryotic Translation Initiation Factor 2 alpha kinase 4, Eif2ak4, EIF2AK4, E2AK4 |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-GCN2 antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-GCN2 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-GCN2 antibody. Counter stained with hematoxylin. 4. ICC staining GCN2 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining GCN2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining GCN2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of MCF-7 cells with GCN2 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-200; ICC: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The family of stress-responsive protein kinases include HRI (heme-regulated inhibitor or EIF2AK1), PKR (EIF2AK2 or TIK), PERK (EIF2AK3) and GCN2 (EIF2AK4). These proteins phosphorylate the eukaryotic translation initiation factor 2α (eIF2α) on Ser 51 to regulate general and gene-specific protein synthesis. Phosphorylated eIF2α acts as an inhibitor of its guanine nucleotide exchange factor eIF2B. GCN2, a unique eIF2α kinase, exists in all eukaryotes from yeast to mammals. In mammals, expression of GCN2 is highest in liver and brain tissues. GCN2 primarily initiates the phosphorylation of eIF2α in response to UV, but has been shown to increase phosphorylation activity in response to serum starvation. Also, substitution of Asp 83 for Ala on eIF2α results in impaired phosphorylation by GCN2 and PKR, suggesting a contribution of remote residues to kinase-substrate recognition. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 187 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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