Urocortin (rat) acetate

Name: Urocortin (rat) acetate
Brand: TargetMol
SKU: TP1020L
Rating: 4.5 (1 reviews)

(Synonyms: Urocortin (rat) acetate (171543-83-2 Free base)) Copy Product Info

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Synonyms: Urocortin (rat) acetate (171543-83-2 Free base)

Catalog No. TP1020L Copy Product Info

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Urocortin (rat) acetate is a potent, selective CRFR agonist with Ki values of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α, and mouse CRF2β, respectively. Urocortin (rat) acetate exhibits cardioprotective, anti-inflammatory, and immunomodulatory activities. Urocortin (rat) acetate can be used in cardiovascular protection and immune-inflammatory research.

Pack Size	Price	USA Stock	Global Stock
1 mg	$159	Inquiry	Inquiry
5 mg	$395	Inquiry	Inquiry
10 mg	$563	Inquiry	Inquiry
25 mg	$828	Inquiry	Inquiry
50 mg	$1,130	Inquiry	Inquiry
100 mg	$1,530	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Urocortin (rat) acetate is a potent, selective CRFR agonist with Ki values of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α, and mouse CRF2β, respectively. Urocortin (rat) acetate exhibits cardioprotective, anti-inflammatory, and immunomodulatory activities. Urocortin (rat) acetate can be used in cardiovascular protection and immune-inflammatory research.
Targets & IC50	CRF2α (rat):0.063 nM (EC50), CRF1 (human):0.15 nM (EC50), CRF2β (mouse):0.087 nM (EC50)
In vitro	Urocortin (rat) acetate induces cAMP generation with EC50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively in stably transfected Chinese hamster ovary cells[1].
In vivo	Urocortin (rat) acetate (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect was observed in mice after Urocortin (1 μg; i.c.v.) administration[2].
Synonyms	Urocortin (rat) acetate (171543-83-2 Free base)

Chemical Properties

Smiles	CC[C@@H]([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H]2CCCN2C([C@@H](NC([C@@H](N)CC(O)=O)=O)CC(O)=O)=O)=O)=O)CC(C)C)=O)CO)=O)[C@H](CC)C)=O)CC(O)=O)=O)CC(C)C)=O)[C@H](O)C)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)[C@H](O)C)=O)CC(C)C)=O)CC(C)C)=O)CCC(O)=O)=O)CC(C)C)=O)C)=O)CCCNC(N)=N)=O)[C@H](O)C)=O)CCC(N)=O)=O)CO)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)C)=O)CCC(O)=O)=O)CCC(N)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C(C)C)=O)CO)=O)CC(O)=O)=O)CC5=CC=CC=C5)=O)[C@H](CC)C)=O)C.O=C(O)C
Relative Density.	no data available
Sequence	Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val
Sequence Short	DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc