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p-Hydroxycinnamic acid

Name: p-Hydroxycinnamic acid
Brand: TargetMol
SKU: T7053
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7053Cas No. 7400-08-0

Alias p-Hydroxy-cinnamic acid, p-Cumaric acid, p-Coumaric acid, NSC 59260

p-Hydroxycinnamic acid (NSC-59260) can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.

p-Hydroxycinnamic acid

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Purity: 99.83%

Catalog No. T7053Alias p-Hydroxy-cinnamic acid, p-Cumaric acid, p-Coumaric acid, NSC 59260Cas No. 7400-08-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 g	$42	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	p-Hydroxycinnamic acid (NSC-59260) can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
Targets&IC50	Prostaglandin E2:126 μM, TXB2:371 μM
In vitro	p-Hydroxycinnamic acid (500 μM and 1 mM) reduces ADP-induced platelet aggregation (55?2 (SE 4?01) % and 35?6 (SE 2?35) % relative to the basal level, respectively). p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary hemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (IC50 371 and 126 μM, respectively)[1].
Synonyms	p-Hydroxy-cinnamic acid, p-Cumaric acid, p-Coumaric acid, NSC 59260

Chemical Properties

Molecular Weight	164.16
Formula	C₉H₈O₃
Cas No.	7400-08-0
Smiles	C(=CC(O)=O)C1=CC=C(O)C=C1
Relative Density.	1.329 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6.25 mg/mL (38.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (6.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0916 mL	30.4581 mL	60.9162 mL	304.5809 mL
5 mM	1.2183 mL	6.0916 mL	12.1832 mL	60.9162 mL
10 mM	0.6092 mL	3.0458 mL	6.0916 mL	30.4581 mL
20 mM	0.3046 mL	1.5229 mL	3.0458 mL	15.2290 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc