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Anti-Phospho-HP1 alpha (Ser92) Polyclonal Antibody
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Catalog No. TMAB-10812
Anti-Phospho-HP1 alpha (Ser92) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HP1 alpha (Ser92). Anti-Phospho-HP1 alpha (Ser92) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-HP1 alpha (Ser92) Polyclonal Antibody
Anti-Phospho-HP1 alpha (Ser92) Polyclonal Antibody
😃Good
Catalog No. TMAB-10812
Anti-Phospho-HP1 alpha (Ser92) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HP1 alpha (Ser92). Anti-Phospho-HP1 alpha (Ser92) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-HP1 alpha (Ser92) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HP1 alpha (Ser92). Anti-Phospho-HP1 alpha (Ser92) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Dog,Pig,Cow,Horse,Sheep) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human HP1 alpha around the phosphorylation site of Ser92 |
| Antigen Species | Human |
| Gene Name | CBX5 |
| Gene ID | |
| Protein Name | Chromobox protein homolog 5 |
| Uniprot ID | |
| Function | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. |
| Molecular Weight | Theoretical: 22 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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