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Anti-Spindly Polyclonal Antibody
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Catalog No. TMAB-13118
Anti-Spindly Polyclonal Antibody is a Rabbit antibody targeting Spindly. Anti-Spindly Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Spindly Polyclonal Antibody
Anti-Spindly Polyclonal Antibody
😃Good
Catalog No. TMAB-13118
Anti-Spindly Polyclonal Antibody is a Rabbit antibody targeting Spindly. Anti-Spindly Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Spindly Polyclonal Antibody is a Rabbit antibody targeting Spindly. Anti-Spindly Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Dog,Pig,Cow) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm, cytoskeleton, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The five integral families of plant hormones consists of auxins, cytokinins, giberellins (GAs), abscisic acid (ABA), and ethylene. Giberellins, which consist of over fifty family members, mediate shoot growth. In Arabidopsis, SPINDLY (SPY) negatively regulates GA signal transduction. ERA1 (enhanced response to absisic acid), which is identical to WIGGUM, controls floral and shoot apical meristem size and floral organ number in response to ABA. Ethylene is perceived by a family of five receptors, one of which is ETR1, whereas CTR1 is a negative regulator of the ethylene signal transduction pathway . Ethylene is also produced endogenously in Arabidopsis via a biosynthetic pathway, which is catalyzed by ACC synthase and ACC oxidase. |
| Immunogen | KLH conjugated synthetic peptide: human Protein Spindly |
| Antigen Species | Human |
| Gene Name | SPDL1 |
| Gene ID | |
| Protein Name | Protein Spindly |
| Uniprot ID | |
| Function | Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. |
| Molecular Weight | Theoretical: 67 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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